PMID: 9426368Jan 14, 1998Paper

Inhibitory effects of antibiotics on platelet aggregation in vitro

Human & Experimental Toxicology
H KariyazonoK Yamada

Abstract

1. We evaluated in vitro inhibitory effects of six types of antibiotic, aztreonam (AZT), cefamandole (CMD), cefmetazole (CMZ), cefotiam (CTM), flomoxef (FMOX) and latamoxef (LMOX), on platelet aggregation, using healthy volunteers' blood. Four types--FMOX, LMOX, CTM and CMD--inhibited, in concentration of 2500 micrograms/ml, the secondary aggregation induced by 3.0 microM adenosine diphosphate (ADP), and also inhibited the aggregation induced by 0.5 micrograms/mi collagen. AZT in the same concentration, did not inhibit the aggregation induced by collagen, and it inhibited only ADP-induced aggregation. CMZ, in the same concentration, inhibited neither of the two aggregations. 2. The inhibitory effects of the antibiotics on collagen-induced aggregation were dependent on the concentration of respective antibiotics. When classified by the strength of inhibitory action, LMOX and FMOX were strong, followed by CTM and CMD. The action of AZT and CMZ was weak. In particular, LMOX showed a 32% inhibitory effect at concentration of 50 micrograms/ml, a level near the blood concentration obtained with clinical usual dose. 3. No relationship was observed between inhibitory effects of antibiotics on ADP- or collagen-induced aggregation and th...Continue Reading

References

Nov 13, 1976·Lancet·K AndrassyH Storch
Nov 1, 1979·The Journal of Clinical Investigation·J S Bennett, G Vilaire
Jan 1, 1988·Drugs·K SunakawaY Ichihashi
Jan 7, 1983·JAMA : the Journal of the American Medical Association·M R Weitekamp, R C Aber
Nov 1, 1982·Reviews of Infectious Diseases·N U BangL E Mattler
Mar 1, 1983·Annals of Internal Medicine·S G Jenkinson
Sep 1, 1983·The Journal of Infectious Diseases·L Uotila, J W Suttie
Jan 1, 1994·Scandinavian Journal of Thoracic and Cardiovascular Surgery·K SaatvedtT Frøysaker

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Citations

Apr 4, 2006·American Journal of Veterinary Research·Jinelle A WebbPatricia A Gentry
Aug 26, 1999·Human & Experimental Toxicology·K NakamuraK Yamada
Aug 16, 2001·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·K NakamuraK Yamada
Apr 20, 2004·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Hiroko KariyazonoKatsushi Yamada

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