Inhibitory effects of anticonvulsant drugs on cyclic nucleotide accumulation in brain

Annals of Neurology
J A Ferrendelli, D A Kinscherf


Veratridine causes deplorization of excitable cells and produces marked elevation of adenosine 3',5'-monophosphate (cyclic AMP) and guanosine 3',5'-monophosphate (cyclic GMP) levels in incubated slices of mouse cerebral cortex. Phenytoin, carbamazepine, phenobarbital, primidone, phensuximide, methsuximide, alpha-methyl-alpha-phenylsuccinimide, and high concentrations of clonazepam are anticonvulsant drugs that preferentially prevent maximal electroshock seizures (MES) and generalized tonic-clonic convulsions; all these agents inhibit veratridine-induced accumulation of both cyclic AMP and cyclic GMP. In contrast, ethosuximide, trimethadione, valproic acid, and low concentrations of clonazepam are anticonvulsant drugs that act predominantly against Metrazol and absence seizures; these agents are ineffective or inhibit accumulation of only cyclic GMP. The results suggest that inhibition of cyclic AMP and cyclic GMP accumulation in depolarized brain tissue is a molecular neuropharmacological action characteristic of anticonvulsant drugs that have direct effects on cellular membrane function and prevent MES. Anticonvulsant drugs that do not inhibit accumulation of both cyclic AMP and cyclic GMP in depolarized brain tissue preferent...Continue Reading


Jan 1, 1990·European Archives of Psychiatry and Neurological Sciences·L LykourasC Stefanis
Jun 15, 1990·Biochemical Pharmacology·C BovinaM Marchetti
Nov 23, 1979·European Journal of Pharmacology·E Chung Hwang, M H Van Woert
Jan 1, 1980·Neurochemistry International·J A FerrendelliO H Lowry
Jan 1, 1983·Progress in Neuro-psychopharmacology & Biological Psychiatry·R M PostP W Gold
Jan 1, 1982·Progress in Neurobiology·J A Richter, J R Holtman
Jan 29, 2002·Pharmacology, Biochemistry, and Behavior·Elzbieta LuchowskaEwa M Urbańska
Dec 1, 2002·Clinical Neuroscience Research·T D GouldH K Manji
Apr 1, 1988·Veterinary and Human Toxicology·R D Kimbrough
Dec 1, 1979·Acta Neurologica Scandinavica·J ParnasL Gram
Sep 16, 2014·Pflügers Archiv : European journal of physiology·Chiung-Wei Huang, Chung-Chin Kuo
Mar 1, 1989·Medical Toxicology and Adverse Drug Experience·L DurelliR Cavallo


Apr 1, 1976·Journal of Neurochemistry·J A FerrendelliD A Kinscherf
Sep 1, 1977·Epilepsia·J A Ferrendelli, D A Kinscherf
Jan 1, 1972·Archives of Neurology·J H Pincus
Jul 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·R J LipickyI M Stillman

Related Concepts

Cyclic AMP, (R)-Isomer
Non-epileptic Convulsion
Cyclic GMP
Thrombocytopenia, Cyclic

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Synapse Loss as Therapeutic Target in MS

As we age, the number of synapses present in the human brain starts to decline, but in neurodegenerative diseases this occurs at an accelerated rate. In MS, it has been shown that there is a reduction in synaptic density, which presents a potential target for treatment. Here is the latest research on synapse loss as a therapeutic target in MS.

Artificial Intelligence in Cardiac Imaging

Artificial intelligence (ai) techniques are increasingly applied to cardiovascular (cv) medicine in cardiac imaging analysis. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

Social Learning

Social learning involves learning new behaviors through observation, imitation and modeling. Follow this feed to stay up to date on the latest research.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Single Cell Chromatin Profiling

Techniques like ATAC-seq and CUT&Tag have the potential to allow single cell profiling of chromatin accessibility, histones, and TFs. This will provide novel insight into cellular heterogeneity and cell states. Discover the latest research on single cell chromatin profiling here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.