Inhibitory effects of azelastine and tranilast on leukotriene B4 and leukotriene C4 generation by rat colonic mucosa

Prostaglandins, Leukotrienes, and Essential Fatty Acids
T ShimizuK Yabuta

Abstract

Anti-allergic drugs such as sodium cromoglycate are known to be effective for the treatment of ulcerative colitis (UC). Because leukotriene (LT) production is considered to play an important role in the pathophysiology of UC, we examined the effect of the anti-allergic drugs, azelastine and tranilast, and the 5-lipoxygenase inhibitor, AA861, on LTB4 and LTC4 production by isolated rat colonic mucosa treated with the calcium ionophore, A23187. Preincubation of colonic mucosa with AA861 (10(-4) M) or azelastine (10(-4) M) significantly reduced AA23187-induced LTB4 (p < 0.01 and p < 0.05, respectively) and LTC4 (p < 0.01) production. Pretreatment with tranilast (10(-3) M) also significantly reduced A23187-induced LTC4 production (p < 0.05). These findings suggest that azelastine and tranilast can inhibit LT production in colonic mucosa and may be beneficial in the treatment of patients with UC.

References

Jan 1, 1990·Japanese Journal of Pharmacology·K TaniguchiK Takanaka
Jan 1, 1987·Biomedical Chromatography : BMC·B Odlander, H E Claesson

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Citations

Aug 7, 2009·The Journal of Investigative Dermatology·Tsugunobu AndohYasushi Kuraishi
Jul 31, 2012·Immunity·Michael F Gurish, K Frank Austen

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