Inhibitory effects of Baicalin on ultraviolet B-induced photo-damage in keratinocyte cell line

The American Journal of Chinese Medicine
Wei MinDan Luo

Abstract

Baicalin, one kind of Chinese herbal medicine with anti-inflammatory and anti-oxidant property, has been commonly used as a clinical medicine. However, little has been known about the effects of Baicalin on ultraviolet (UV) induced photo-aging and photo-carcinogenesis. The photoproduct is critical to the initial event of UV-induced photo-carcinogenesis. The purpose of the present study was to investigate whether Baicalin, in immortalized human keratinocyte HaCaT cells, could inhibit ultraviolet-B (UVB) induced skin damage and its possible underlying mechanisms, such as inhibiting UVB-induced cytotoxicity and apoptosis, cyclobutane pyrimidine dimers (CPDs), down-regulating the expression of regulatory proteins which are related to cell apoptosis and DNA damage/repair. Our study revealed that Baicalin treatment could inhibit the UVB-induced cytotoxicity, apoptosis and CPD level. It also decreased the mRNA expression of apoptosis-regulatory genes (p53-p21 and c-fos), the protein levels of p53, proliferating cell nuclear antigen (PCNA) and repair protein A (RPA), and the secretion of cytokines [interleukin(IL)-6 and tumor necrosis factor (TNF-alpha)]. These results suggested that Baicalin may have an inhibitory effect on the UVB-in...Continue Reading

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Citations

May 30, 2014·The American Journal of Chinese Medicine·Wei MinDan Luo
Nov 20, 2012·Journal of Dermatological Science·Ze GuoDan Luo
Dec 2, 2015·Phytotherapy Research : PTR·Jin Kyung SeokYong Chool Boo
Sep 15, 2009·Photodermatology, Photoimmunology & Photomedicine·Bing-Rong ZhouDan Luo
Feb 5, 2013·Journal of Chromatographic Science·Cen ChenWen Xiao
Apr 14, 2010·The American Journal of Chinese Medicine·Muneo TsukiyamaYukihiro Shoyama
Apr 8, 2017·The American Journal of Chinese Medicine·Dan LiWei Min

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