Abstract
The effects of alpha-carotene, beta-carotene, palm carotene, and green tea polyphenols (GTP) on the progression stage of pancreatic carcinogenesis after rapid production of ductal lesions were studied in Syrian hamsters. Dose threshold inhibitory effects were noted for beta-carotene, 25 ppm, and palm carotene, 40 ppm, which includes 24 ppm beta-carotene reducing the numbers of putative preneoplastic lesions of duct epithelial hyperplasia and atypical hyperplasia, as well as carcinoma in situ and invasive carcinomas. GTP at doses of 500 and 5000 ppm, but not 100 ppm, also significantly decreased the numbers of hyperplasia and total duct lesions. Combined administration of 40 ppm palm carotene, and 50 ppm GTP similarly inhibited the lesion development. Alpha-carotene, however, did not affect pancreatic carcinogenesis. The results suggest that chemopreventive effects are exerted by beta-carotene and GTP above critical doses and that combined administration of palm carotene and GTP might be a candidate chemoprevention strategy for pancreatic cancer in humans.
Citations
Dec 23, 2003·Pathology Oncology Research : POR·Attila Zalatnai
Nov 1, 2012·Cancer Letters·Srinivas Reddy Boreddy, Sanjay K Srivastava
Apr 8, 2004·Toxicology Letters·Ock Jin Park, Young-Joon Surh
Mar 12, 2003·Mutation Research·Joshua D Lambert, Chung S Yang
Aug 15, 2000·Cancer Letters·X TanD Zhou
May 23, 2001·Cancer Letters·M HiroseT Shirai
Jul 7, 1999·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·G Mathé
May 5, 2010·Nature Reviews. Gastroenterology & Hepatology·Silvia D StanRandall E Brand
Jun 1, 2000·Nutrition Research Reviews·G G DuthieJ A Kyle
Nov 24, 1999·Current Opinion in Clinical Nutrition and Metabolic Care·W AndlauerP Fürst
Jan 25, 2002·Annual Review of Pharmacology and Toxicology·Chung S YangXiaofeng Meng
Dec 20, 2007·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Juhua LuoUNKNOWN JPHC Study Group
Oct 30, 2014·Nutrients·Jin-Long ZengHai-Liang Zhang
Sep 5, 2012·Cancer Epidemiology·Jing WangYu-Tang Gao
Jan 19, 2011·Cancer Science·Claudia KürbitzAnna Trauzold
Nov 26, 2011·Proteomics·Lifeng ZhangQing-Yi Lu
Nov 7, 2006·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·F KhalloukiR W Owen
Jul 19, 2006·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·H DoucasD P Berry
Aug 20, 2005·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·G GarceaD P Berry
Apr 29, 2008·Cancer Letters·Lorne J Hofseth
Jan 1, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Sudhir K DuttaPadmanabhan P Nair
Oct 26, 2000·Japanese Journal of Cancer Research : Gann·M TsutsumiY Konishi
Aug 8, 2015·Metabolomics : Official Journal of the Metabolomic Society·Qing-Yi LuWai-Nang Lee
Jul 28, 2007·Life Sciences·Naghma Khan, Hasan Mukhtar
Apr 24, 2007·Carcinogenesis·Yoshito TakeuchiKeiji Wakabayashi
Apr 16, 2002·Journal of Internal Medicine·R M TamimiD Trichopoulos
Jan 1, 2008·Journal of Dietary Supplements·Chengguo XingPaul J Limburg
Jan 26, 2018·Journal of Berry Research·Pan PanLi-Shu Wang
Feb 17, 2021·Nutrition and Cancer·Masaru TerasakiMichihiro Mutoh