PMID: 3746163Aug 1, 1986Paper

Inhibitory effects of bromocriptine on mammary development and function in lactating mice

The Journal of Endocrinology
C H KnightD J Flint

Abstract

Five experiments were conducted. In the first, the plasma prolactin concentration of lactating mice was significantly reduced 3, 6 and 12 h after a single injection of 0.2 mg bromocriptine at 09.00 h, but recovered to normal levels at 24 h. A second injection at 17.00 h (i.e. total dose of 0.4 mg) completely prevented this recovery. Prolactin concentration was also reduced after the s.c. implantation of a solid pellet of bromocriptine. Once daily injections of bromocriptine for 7 days starting 1-day prepartum (early lactation group) or on day 5 of lactation (established lactation group) significantly reduced milk yield, assessed from the weight gain of the litter or estimated by a tritiated water dilution procedure. In early lactation the degree of inhibition was positively related to the size of the suckling litter (three pups, no inhibition; nine pups, 16.4% inhibition; 14 pups, 40.8% inhibition), but in established lactation an inhibition of 25-30% was observed, regardless of litter size. Twice-daily injections and s.c. implants of bromocriptine both reduced milk yield by a greater amount (approximately 45%), but in no case was secretion completely suppressed. The inhibitory effect of bromocriptine was prevented by the simul...Continue Reading

Citations

Apr 7, 2011·American Journal of Physiology. Endocrinology and Metabolism·Michael C RudolphSteven M Anderson
Oct 15, 1998·Proceedings of the National Academy of Sciences of the United States of America·D WynickV Pachnis
Feb 3, 1999·Annals of the New York Academy of Sciences·D WynickV Pachnis
May 29, 2018·Brain Structure & Function·Szilvia OláhArpád Dobolyi
Sep 1, 1987·Journal of Dairy Science·C H Knight, C J Wilde

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