PMID: 16538005Mar 16, 2006Paper

Inhibitory effects of caraway (Carum carvi L. ) and its component on N-methyl-N'-nitro-N-nitrosoguanidine-induced mutagenicity

The Journal of Medical Investigation : JMI
Masanori MazakiYoshinari Ohnishi

Abstract

To elucidate the mechanism of antimutagenicity of caraway, we examined the effects of caraway seed extract on N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced mutagenesis in DNA methyltransferase-deficient Salmonella typhimurium strains, O6-methylguanine DNA adduct formation, and thiol content in S. typhimurium cells. MNNG was highly mutagenic for ogt- strains YG7104 (ogt- ada+) and YG7108 (ogt- ada-), and it showed slightly higher mutagenicity in strain YG7100 (ogt+ ada-) than in strains TA100 and TA1535. Hot water extract of caraway seeds inhibited MNNG-induced mutation only in the ogt+ strains. In the presence of caraway extract, O6-methylguanine DNA adducts in strain YG7100 were decreased in proportion to the decrease of MNNG-induced mutagenesis. Although MNNG is known to degrade in the presence of thiols to produce methyl cation which can react with DNA, caraway had no effect on cellular concentrations of acid-soluble thiols. These results indicate that caraway does not directly inactivate MNNG and that Ogt-O6-methylguanine-DNA methyltransferase may be involved in the antimutagenic activity of caraway.

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Citations

Nov 19, 2011·Pharmacognosy Reviews·R K Johri
Nov 27, 2009·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·F FatemiJ Ashrafihelan
Dec 10, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Mahnaz KazemipoorGeoffrey A Cordell
Apr 27, 2011·Pharmaceutical Biology·Abolfazl Dadkhah, Faezeh Fatemi
Jan 24, 2007·Epilepsia·Shin-Ichiro HamanoYoshikatsu Eto

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