Dec 1, 1962

Inhibitory effects of carbohydrates on histamine release and mast cell disruption by dextran

British Journal of Pharmacology and Chemotherapy
W T BERALDOA D FERNANDES

Abstract

Alloxan diabetic rats failed to show the skin reaction (blue spot) evoked by dextran, whereas the effects produced by histamine and compound 48/80 were not altered. When dextran and glucose were injected simultaneously into the skin the reaction was inhibited. In vitro, mast cell alterations produced by dextran occurred simultaneously with histamine release; both processes were inhibited by glucose, other carbohydrates related to glucose, and inhibitors of anaphylaxis. These experiments suggest that dextran releases histamine by a mechanism similar to that found with 48/80 and anaphylaxis in the rat. The inhibitory effect of carbohydrates may be understood on the basis of a competitive mechanism.

  • References10
  • Citations18

References

  • References10
  • Citations18

Mentioned in this Paper

Histamine Measurement
Carbohydrate nutrients
Anaphylaxis (Non Medication)
Mast Cell
Glucose, (beta-D)-Isomer
Streptozotocin Diabetes
Anaphylaxis
Allergy Testing Histamine (Lab Test)
Alloxan
Histamine

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Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.

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