Inhibitory effects of compounds from Zingiberaceae species on platelet activating factor receptor binding

Phytotherapy Research : PTR
Ibrahim JantanJuriyati Jalil

Abstract

Ten compounds isolated from Alpinia mutica Roxb., Curcuma xanthorrhiza Roxb. and Kaempferia rotunda Linn. (Family: Zingiberaceae) were investigated for their platelet-activating factor (PAF) antagonistic activities on rabbit platelets using 3H-PAF as a ligand. Among them, four compounds showed significant inhibitory effects. Alpinetin and 5,6-dehydrokawain isolated from A. mutica exhibited IC50 values of 41.6 and 59.3 microM, respectively. The IC50 values of 3-deacetylcrotepoxide and 2-hydroxy-4,4',6'-trimethoxychalcone from K. rotunda were 45.6 and 57.4 microM, respectively. 1-Methoxy-2-methyl-5-(1',5'-dimethylhex-4'-enyl)-benzene, synthesized by methylation of xanthorrhizol which was obtained from C. xanthorrhiza, showed an IC50 value of 40.9 microM. The results indicated that these compounds were relatively strong PAF receptor binding inhibitors.

References

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Citations

Sep 6, 2012·Natural Product Research·Hasnah Mohd Sirat, Nor Akmalazura Jani
Jan 18, 2014·Journal of Medicinal Food·Luís Moreira GonçalvesJosé António Rodrigues
Jul 5, 2007·The Journal of Sexual Medicine·Hatta SidiMarhani Midin
Oct 5, 2007·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·I JantanJ A Jamal
Nov 20, 2012·Fitoterapia·Preeti SinghVipin Kumar Garg
Aug 18, 2010·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bushra Abdulkarim MoharamJuriyati Jalil

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