PMID: 6410461May 1, 1983Paper

Inhibitory effects of cysteamine on neuroendocrine function

Regulatory Peptides
W B WehrenbergR Guillemin

Abstract

The action of cysteamine on anterior pituitary hormone secretion was studied in vivo using conscious, freely moving male rats and in vitro using anterior pituitary cells in monolayer culture. Administration of 500 micrograms cysteamine into the lateral cerebral ventricles of normal rats caused the complete inhibition of pulsatile GH secretion for a minimum of 6 h. This treatment also significantly decreased plasma concentrations of LH for at least 6 h in orchiectomized rat, TSH in short-term (0.5 month) thyroidectomized rats, and PRL in long-term (6 months) thyroidectomized rats. The in vivo stimulation of GH, LH, TSH and PRL with their respective releasing hormones 60 min after administration of cysteamine was not different from the response observed in rats pretreated with saline except for PRL where cysteamine pretreatment significantly inhibited the expected PRL increase. In vitro, 1 mM cysteamine decreased basal and TRH stimulated PRL release while not affecting basal or stimulated GH, LH, TSH and ACTH secretion. These data demonstrate the dramatic and wide-ranging effects of cysteamine on anterior pituitary hormone secretion. This action appears to be mediated through hypothalamic pathways for GH, LH and TSH and through a...Continue Reading

References

Aug 14, 1980·Biochemical and Biophysical Research Communications·N LingR Guillemin
Dec 1, 1981·Endocrinology·S Szabo, S Reichlin
May 20, 1982·Brain Research·M PalkovitsS Szabo
Feb 1, 1983·Endocrinology·W J MillardJ B Martin
Nov 30, 1982·Biochemical and Biophysical Research Communications·W B WehrenbergR Guillemin
Jan 18, 1982·Life Sciences·T M BadgerP Rosenblum
Jul 30, 1982·Science·W J MillardJ B Martin

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Citations

Jun 1, 1986·Pharmacology, Biochemistry, and Behavior·M T Martin-IversonS R Vincent
Jan 1, 1990·Progress in Neuro-psychopharmacology & Biological Psychiatry·L Vécsei, E Widerlöv
Oct 1, 1993·Journal of Pharmaceutical and Biomedical Analysis·H KataokaM Makita
Nov 5, 1997·Pharmacology, Biochemistry, and Behavior·D Feifel, K L Minor
Aug 30, 1985·Biochimica Et Biophysica Acta·C G Ostenson, S Efendić
Dec 15, 2006·Medical Hypotheses·Chi-Un PaeIn-Ho Paik

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