Abstract
We have previously reported that dauricine exerted antiarrhythmic effects on various experimental arrhythmias. To further clarify its mechanism, the effects of dauricine on action potential duration (APD), early afterdepolarizations (EADs), triangulation, which is defined as the repolarization time from APD at 30% level (APD30) to APD at 90% level (APD90), and L-type calcium current (I(Ca-L)) were studied using standard microelectrode techniques on rabbit papillary muscles and whole-cell patch clamp techniques on single myocytes isolated from rabbits by enzymatic digestion, respectively. Cardiac hypertrophy was induced by coarctating the abdominal aorta of rabbits. The results showed that in papillary muscles of hypertrophied rabbits, 1 micromol/L dofetilide, a selective IKr blocker, prolonged APD50 and APD90 and induced EADs (4/6, p < 0.01) with hypokalemia ([K+]o = 2.7 mmol/L). Dauricine inhibited EADs (p < 0.01) and shortened the prolonged APD (p < 0.01). In single myocytes, dauricine also inhibited EADs induced by dofetilide, hypokalemia, and hypomagnesaemia. Dauricine decreased the triangulation and reduced the peak amplitude of I(Ca-L) at all potentials tested. Dauricine shifted the steady-state activation curves to the r...Continue Reading
References
May 1, 1989·Circulation Research·C T January, J M Riddle
Mar 1, 2000·Journal of Cardiovascular Electrophysiology·L EckardtM Borggrefe
Aug 5, 2000·European Heart Journal·A J CammS M Cobbe
Apr 18, 2001·Circulation·L M HondeghemG Duker
May 4, 2001·Cardiovascular Research·L M HondeghemF De Clerck
Jun 13, 2001·Circulation·G X YanP R Kowey
Nov 28, 2001·Circulation·J M van OpstalM A Vos
Sep 18, 2002·The Journal of Pharmacology and Experimental Therapeutics·Peter MilbergWilhelm Haverkamp
Oct 2, 2002·European Journal of Pharmacology·Hua Rong LuFred De Clerck
Mar 11, 2003·Journal of Cardiovascular Electrophysiology·Charles AntzelevitchMarc Vos
Apr 2, 2003·Cardiovascular Research·W S RedfernT G Hammond
Dec 5, 2003·Trends in Pharmacological Sciences·Luiz BelardinelliMarc A Vos
Jun 3, 2004·Journal of Pharmacological and Toxicological Methods·Jean-Pierre ValentinLuc Hondeghem
Jun 11, 2004·European Journal of Pharmacology·Kenji TsujimaeYoshihisa Kurachi
Aug 11, 2004·Circulation·Gan-Xin YanPeter R Kowey
Jan 11, 2007·Journal of Cardiovascular Electrophysiology·Donglin GuoGan-Xin Yan
Feb 28, 2007·Clinical and Experimental Pharmacology & Physiology·Zhi-Jiang HuangYin Dai
Jul 24, 2008·Naunyn-Schmiedeberg's Archives of Pharmacology·Stefan DheinFriedrich-Wilhelm Mohr
Citations
Sep 17, 2011·Journal of Ethnopharmacology·Jing ZhaoShuangqing Peng
Jul 15, 2015·BioMed Research International·Zhi-Jie YueZhi-Bin Yu
Mar 8, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bo ZhaoLian-Jun Guo
May 28, 2020·Frontiers in Genetics·Faiza HinaChengxin Fu
Oct 16, 2019·Oncology Letters·Ying-Bo ZhangLi-Li Zhong
Jul 17, 2020·Journal of Traditional and Complementary Medicine·Ahmad BeikHamid Najafipour