Inhibitory effects of Egyptian folk medicines on human immunodeficiency virus (HIV) reverse transcriptase

Chemical & Pharmaceutical Bulletin
S el-MekkawyT Namba

Abstract

Extracts of 41 medicinal plants used in Egyptian folk medicine were screened for their inhibitory effects on human immunodeficiency virus-1 reverse transcriptase. The extracts of fruits of Phyllanthus emblica, Quercus pedunculata, Rumex cyprius, Terminalia bellerica, Terminalia chebula and Terminalia horrida showed significant inhibitory activity with IC50 < or = 50 micrograms/ml. Through a bioassay guided-fractionation of the methanol extract of the fruit of P. emblica, putranjivain A (1) was isolated as a potent inhibitory substance with IC50 = 3.9 microM, together with 1,6-di-O-galloyl-beta-D-glucose (2), 1-O-galloyl-beta-D-glucose (3), kaempferol-3-O-beta-D-glucoside (4), quercetin-3-O-beta-D-glucoside (5) and digallic acid (6). The inhibitory mode of action by 1, 2 and 6 was non-competitive with respect to the substrate but competitive with respect to a template-primer. Furthermore, the stereochemistry of 1 was established in this paper by nuclear magnetic resonance spectroscopy.

Citations

Mar 5, 2008·Evidence-based Complementary and Alternative Medicine : ECAM·Yogesh S BiradarSmita S Singhania
Dec 24, 2008·AIDS Research and Therapy·M FrittsS A Andrade
Jan 29, 2013·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Seyed Hamid KamaliSeyed Ali Kamali
Jan 1, 2012·African Journal of Traditional, Complementary, and Alternative Medicines : AJTCAM·Seewaboon SireeratawongNoppamas Soonthornchareonnon
Jan 31, 2006·Molecular and Cellular Biochemistry·Ramasundaram SrikumarRathinasamy Sheeladevi
Mar 14, 2002·Journal of Ethnopharmacology·Kavita Vermani, Sanjay Garg
Jul 25, 2000·Journal of Ethnopharmacology·P Scartezzini, E Speroni
Feb 22, 2008·Journal of Ethnopharmacology·Anwarul Hassan GilaniSaad Ajmal
Sep 19, 2015·Journal of Ethnopharmacology·Andrea VasasJudit Hohmann
Jul 13, 2006·Phytotherapy Research : PTR·S ThamburanQ Johnson
Jan 18, 2005·Journal of Ethnopharmacology·Swayamjot KaurSubodh Kumar
Dec 24, 2013·Toxicology and Applied Pharmacology·Hui-Hun KimSang-Hyun Kim
Sep 19, 2007·Biotechnology Annual Review·Mahmud Tareq Hassan Khan, Arjumand Ather
Nov 1, 1996·Transactions of the Royal Society of Tropical Medicine and Hygiene·P J Houghton
Aug 5, 2005·Biological & Pharmaceutical Bulletin·Ramasundaram SrikumarRathinasamy Sheela Devi
Mar 31, 2005·Journal of Pharmaceutical and Biomedical Analysis·A KumarA N Garg
May 15, 2018·International Journal of Molecular Sciences·Bahare SalehiJavad Sharifi-Rad
Jun 10, 2004·Biological & Pharmaceutical Bulletin·Maira Huerta-ReyesRicardo Reyes-Chilpa
Jun 1, 2001·Chemical & Pharmaceutical Bulletin·Y J ZhangI Kouno
Nov 6, 2007·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Selvakumar DhanalakshmiRamasundaram Thangaraj
May 6, 2010·International Journal of Occupational Medicine and Environmental Health·Devjani Chakraborty, Ramtej Verma
May 18, 2007·The British Journal of Nutrition·Takako YokozawaLekh Raj Juneja
Nov 11, 2006·IDrugs : the Investigational Drugs Journal·Letitia Perry, Andrew Balfe
Nov 29, 2017·Pharmaceutical Biology·Walaa A El-KashakIñaki Brouard
Aug 1, 2019·Clinical and Experimental Pharmacology & Physiology·Umme LailaSaeed Ahmad
May 6, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ramandeep KaurDinesh Kumar
May 29, 2010·Journal of Basic and Clinical Physiology and Pharmacology·Mani Krishnaveni, Sankaran Mirunalini
Feb 16, 2017·BMC Complementary and Alternative Medicine·Ajay KesharwaniSatish Kumar Gupta
Apr 20, 2002·Chemical & Pharmaceutical Bulletin·Sahar El-MekkawyToru Otake
Feb 6, 2004·Biological & Pharmaceutical Bulletin·Ying-Jun ZhangIsao Kouno

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