Inhibitory effects of Euterpe oleracea Mart. on nitric oxide production and iNOS expression

Journal of Ethnopharmacology
Maria Eline MatheusPatrícia D Fernandes

Abstract

The palm Euterpe oleracea is a plant of great economic value in Brazil. Although the heart of palm extracted from its trunk is considered a delicacy the world over, its fruits are popular only among Brazilians. In some poor regions of Brazil, there are reports on the popular use of its juice in the treatment of several disorders, mainly those of oxidative onset as cardiovascular ones. Because of its wide utilization; because there are very few scientific studies of this species, and to discover if its use in folk medicine for problems related with oxidation is in fact justifiable, we decided, in this study, to evaluate the effects of Euterpe oleracea flowers, fruits and spikes fractions on: nitric oxide (NO) production, NO scavenger capacity, and on the expression of inducible nitric oxide synthase enzyme, as well. Results showed that the fractions obtained from fruits were the most potent in inhibiting NO production, followed by those from flowers and spikes. Only in high doses, did some fractions reduce cell viability. Reduction on NO production was not due to NO scavenger activity. These results were accompanied by inhibition of iNOS expression. The more pronounced effect was observed in the fractions in which the concentrat...Continue Reading

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Citations

Feb 23, 2010·Journal of Medicinal Food·Maria Elisa SchreckingerElvira Gonzalez de Mejia
Dec 26, 2009·Journal of Ethnobiology and Ethnomedicine·Joanna Sosnowska, Henrik Balslev
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Dec 5, 2006·European Journal of Pharmacology·Maria Eline MatheusPatricia Dias Fernandes
Jan 15, 2013·Journal of Ethnopharmacology·Mariana M G PinheiroPatrícia D Fernandes
Feb 28, 2015·Food Chemistry·Klenicy Kazumy de Lima YamaguchiValdir Florêncio da Veiga-Junior
Dec 6, 2011·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Roberto Soares de MouraSamuel Santos Valenca
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