Inhibitory effects of falconensins on 12-O-tetradecanoylphorbol-13-acetate-induced inflammatory ear edema in mice.

Journal of Natural Medicines
Ken YasukawaM Takido

Abstract

Fifteen derivatives of falconensin were examined for their inhibitory activity against the induction of ear edema in mouse ear by application of 12-O-tetradecanoylphorbol-13-acetate (TPA). It was demonstrated that azaphilonoid falconensins exert inhibitory effects against TPA-induced inflammation in the ears of mice to a comparable degree as moascorubrin and indomethacin, which are known to have antitumor-promoting and anti-inflammatory effects. All compounds tested, except monomethylmitorubrin, inhibited the inflammatory activity induced by TPA.

Citations

Jul 9, 2017·Marine Biotechnology·Mei-Yan WeiChang-Lun Shao
Apr 16, 2020·Marine Drugs·Dina H El-KashefPeter Proksch
Apr 16, 2013·Chemical Reviews·Jin-Ming GaoJian-Chun Qin

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