Inhibitory effects of ionic liquids on the lactic dehydrogenase activity

International Journal of Biological Macromolecules
Xing DongShaofeng Hua

Abstract

Ionic liquids (ILs) were widely used in scientific and industrial application and have been reported to possess potential toxicity to the environment and human health. The effects of six typical N-methylimidazolium-based ILs ([Cnmim]X, n=4, 6, 8; X=Br(-), Cl(-), BF4(-), CF3SO3(-)) on the lactic dehydrogenase (LDH) activity and the molecular interaction mechanism of ILs and the LDH were investigated with the aid of spectroscopic techniques. Experimental results showed that the LDH activity was inhibited in the presence of ILs. For the ILs with the same anion but different cations, their inhibitory ability on the LDH activity increased with increasing the alkyl chain length on the IL cation. Thermodynamic parameters, enthalpy change (ΔH) and entropy change (ΔS) were obtained by analyzing the fluorescence behavior of LDH with the addition of ILs. Both positive ΔH and ΔS suggested that hydrophobicity was the major driven force in the interaction process as expected.

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Citations

Apr 11, 2017·ChemSusChem·Susana P F CostaM Lúcia M F S Saraiva
Jul 27, 2017·Chemical Reviews·Toshiyuki Itoh
Oct 5, 2017·Arhiv za higijenu rada i toksikologiju·Marina Cvjetko BubaloVišnja Gaurina Srček
Jan 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Fátima A R MotaM Lúcia M F S Saraiva
May 7, 2021·Journal of Hazardous Materials·Sandra MaginaDmitry V Evtuguin
Mar 24, 2018·International Journal of Biological Macromolecules·Vítor Geniselli da Silva, Ruann Janser Soares de Castro
May 12, 2021·The Science of the Total Environment·Chul-Woong ChoYeoung-Sang Yun
Jun 3, 2021·International Journal of Molecular Sciences·Ana R P GonçalvesCarla S G P Queirós
Nov 24, 2021·Chemical Society Reviews·Penghao WeiBing Yan

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