PMID: 2167654Jan 1, 1990Paper

Inhibitory effects of kampo medicine on Epstein-Barr virus antigen induction by tumor promoter

Auris, Nasus, Larynx
M FurukawaR Umeda


We have investigated the possible interaction of Japanese Kampo medicine; Shosaiko-to with Epstein-Barr virus (EBV) induction by TPA (12-O-tetra-decanoyl-phorbol-13-acetate) in EBV-genome harboring cells. The effect of ether extract of Shosaiko-to was also studied on the induction of EBV by superinfection with EBV from P3HR-1 cells (P3H-EBV). Concomitant treatment of EBV-latently-infected cells (Raji and A2L/AH) with TPA and ether extract resulted in effective inhibition of EBV-antigen induction. However, in the experiments to test the influence of ether extract on EBV induction by superinfecting Raji cells with P3H-EBV, ether extract did not affect the percentage of EBV-antigen-positive cells. These data indicate that Shosaiko-to is effective to inhibit antigen synthesis induced by chemical promoters without affecting EBV-antigen induction after superinfection.


Dec 1, 1975·Japanese Journal of Pharmacology·H NagaiA Koda
Jan 1, 1988·Archives of Oto-rhino-laryngology·K Ikeda, T Takasaka
Jan 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·G Miller, M Lipman
Sep 1, 1981·Preventive Medicine·T Hirayama, Y Ito
Sep 1, 1981·Planta medica·T NikaidoU Sankawa
Mar 1, 1984·The Annals of Otology, Rhinology, and Laryngology·T TakimotoR Umeda


Aug 31, 2019·Medicina·Pasquale De FranciscisAntonio Schiattarella

Related Concepts

Antigens, Viral
Tumor Promoters
Plant Extracts, Chinese
Epstein-Barr Virus
Plant Extracts
Tumor Cells, Cultured
Prophage Induction

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