Inhibitory effects of Leonurus sibiricus on weight gain after menopause in ovariectomized and high-fat diet-fed mice

Journal of Natural Medicines
Jangseon KimWoong Mo Yang

Abstract

Leonurus sibiricus, also called motherwort, is a well-known functional food and medicinal herb. It has been known to possess beneficial properties for women's health, especially for aged women. Estrogen deficiency in the menopause could induce lipid metabolic abnormalities in body fat, resulting in obesity. In this study, the inhibitory effects of L. sibiricus on obesity after the menopause were investigated. Female C57BL/6 mice were ovariectomized and fed high-fat diet (HFD) for 12 weeks. Following an induction period, aqueous extracts of L. sibiricus (LS) were orally administrated for 6 weeks. The body, uterine, and visceral fat weights were measured immediately after the animals were killed. Histological analysis was performed to monitor fat and liver. Serum levels of glucose, triglyceride, total cholesterol, and LDL-cholesterol were evaluated. In addition, the expression of lipases was analyzed. Total body weight was significantly decreased by LS treatment. Histological changes in adipocyte size were shown along with a decrease of visceral fat weight in the LS-treated group. In addition, the fat infiltration of liver was reduced by LS administration. LS-treated mice experienced decreases of serum triglyceride, total cholest...Continue Reading

References

Sep 1, 1993·Journal of Obstetric, Gynecologic, and Neonatal Nursing : JOGNN·L A Bernhard, L Sheppard
Apr 1, 1996·Diabetes Care·E Barrett-ConnorJ A Perlman
Sep 1, 1996·Baillière's Clinical Obstetrics and Gynaecology·J Schaffer, J A Fantl
Mar 23, 1999·Journal of Clinical Epidemiology·I KatoA Zeleniuch-Jacquotte
Nov 9, 2000·Proceedings of the National Academy of Sciences of the United States of America·P A HeineP S Cooke
Nov 13, 2001·Fertility and Sterility·M R SoulesN Woods
Jan 5, 2002·Climacteric : the Journal of the International Menopause Society·M R SoulesN Woods
Mar 16, 2002·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·M ShinodaJ-M Lavoie
Jul 18, 2002·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·Y-Q LiangY Ouchi
Aug 6, 2002·Molecular and Cellular Endocrinology·Y MurataE R Simpson
Sep 12, 2003·Trends in Pharmacological Sciences·Jan-Ake Gustafsson
Nov 20, 2004·Science·Robert ZimmermannRudolf Zechner
Dec 31, 2005·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M Roden
Apr 29, 2006·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Dominique Langin
Apr 7, 2007·Menopause : the Journal of the North American Menopause Society·Dominik RachońWolfgang Wuttke
Feb 12, 2008·Journal of Cellular Physiology·Ping WangJaap Keijer
Dec 9, 2008·Metabolism: Clinical and Experimental·Vitoon SaengsirisuwanChaivat Toskulkao
May 12, 2009·Journal of Ethnopharmacology·Stefano Dall'AcquaGabbriella Innocenti
Jun 12, 2009·Immunopharmacology and Immunotoxicology·Hye-Young ShinTae-Yong Shin
May 6, 2010·Brain Research·Lynda M BrownDeborah J Clegg
Jul 9, 2010·Lancet·Varman T SamuelGerald I Shulman
Sep 4, 2012·Antioxidants & Redox Signaling·Tomas Jelenik, Michael Roden
Sep 18, 2012·Climacteric : the Journal of the International Menopause Society·S R DavisUNKNOWN Writing Group of the International Menopause Society for World Menopause Day 2012
Feb 23, 2013·Endocrinology·Tomas Jelenik, Michael Roden
Jun 6, 2013·Journal of Natural Medicines·Yuji NarukawaFumiyuki Kiuchi
Mar 19, 2014·Molecular Metabolism·Jun Ho KimFranck Mauvais-Jarvis

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Asprosin

Asprosin is a fasting-induced hormone produced in the white adipose tissue to stimulate the hepatic release of glucose into the bloodstream. Discover the latest research on this protein hormone here.