Inhibitory effects of lodoxamide on eosinophil activation

International Archives of Allergy and Immunology
M CapronA Capron

Abstract

Recent reports describe the beneficial use of lodoxamide, an anti-allergic compound, for the treatment of asthma and allergic conjunctivitis. Lodoxamide is known as a mast cell stabilizer, however, the association of a significant clinical improvement with a specific decrease in eosinophil infiltrate suggested possible direct effects of lodoxamide on eosinophils. The chemotactic response of eosinophils to fMLP as well as to IL-5, in vitro, was very significantly and dose-dependently inhibited by Lodoxamide. Lodoxamide was also able to strongly inhibit the release of eosinophil peroxidase after IgA-dependent activation and, to a lesser extent, the release of eosinophil cationic protein and eosinophil-derived neurotoxin. Moreover, the release of cytotoxic mediators evaluated in an antibody-dependent cytotoxicity assay against parasitic targets was also significantly reduced, not only in the case of human eosinophils but also in a rat eosinophil-mast cell model of cytotoxicity. Taken together, these results indicate that lodoxamide can exert potent inhibitory effects on eosinophil activation in vitro combined with a strong inhibition of eosinophil attraction, leading therefore to a reduction in their pathological potential in vivo.

Citations

Aug 6, 2003·The Journal of Experimental Medicine·Gaetane WoerlyDavid Dombrowicz
Dec 11, 2002·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Katrina L Schmid, Leisa M Schmid
Apr 15, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J D MacLeod
Sep 7, 2004·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G WoerlyM Capron
Nov 19, 2003·European Journal of Ophthalmology·N AcarH Kazokoğlu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antibody-Dependent Cell Cytotoxicity

Antibody-dependent cellular toxicity refers to the lysis of a target cell by a non-sensitized effector cell of the immune system as a result of antibodies binding to the target cell membrane and engaging the Fc receptors on the immune effector cells. Find the latest research on antibody-dependent cellular toxicity here.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Related Papers

Veterinary Ophthalmology
Ana Mafalda Lourenço-MartinsJosé Henrique Duarte Correia
Ocular Immunology and Inflammation
J PalmaresJ Castro-Correia
International Archives of Allergy and Applied Immunology
K MukhopadhyayS S Gambhir
© 2022 Meta ULC. All rights reserved