Inhibitory effects of luteolin on titanium particle-induced osteolysis in a mouse model

Acta Biomaterialia
Dong-Kyu ShinShin-Yoon Kim

Abstract

Wear particles liberated from the surfaces of an implanted prosthesis are associated with peri-implant osteolysis and subsequent aseptic loosening. In the latter wear particle-induced inflammation and osteoclastogenesis have been identified as critical factors, and their inhibition as important steps in the treatment of affected patients, such as those undergoing total hip replacement. In this study the ability of luteolin to inhibit both titanium (Ti) particle-induced osteoclastogenesis in vitro and osteolysis in a murine calvaria Ti particle-induced model of osteolysis was examined. The results showed that luteolin, a highly potent and efficient inhibitor of tumor necrosis factor α (TNF-α) and interleukin-6 expression, inhibited Ti particle-induced inflammatory cytokine release, osteoclastogenesis, and bone resorption in bone marrow macrophages. Microcomputed tomography and histological analyses showed that the Ti particles caused significant bone resorption and increased TRAP(+) multinuclear osteoclasts in the murine calvarial model of osteolysis, whereas this was not the case in the luteolin treatment group, in which osteolytic suppression was accompanied by a decrease in both TNF-α production and serum levels of the osteoc...Continue Reading

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Citations

Jul 6, 2014·Clinical Orthopaedics and Related Research·R Lane Smith, Edward M Schwarz
Mar 19, 2015·The Journal of Oral Implantology·Sathyanarayanan SridharDanieli C Rodrigues
Jun 25, 2015·Biological Trace Element Research·Jiang-Yin-Zi ShangMin Dai
Nov 7, 2012·Journal of Cellular Biochemistry·Gazelle J CrastoMorris F Manolson
Nov 29, 2013·Clinical Implant Dentistry and Related Research·Plinio SennaLuiz Meirelles
Apr 7, 2015·Acta Biomaterialia·Yung-Chang LuChang-Hung Huang
Jun 22, 2016·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Emmanuel GibonStuart B Goodman
Jan 22, 2017·Biochemical and Biophysical Research Communications·Liang ZhuZuo-Qin Yan
Dec 5, 2017·Phytochemistry Reviews : Proceedings of the Phytochemical Society of Europe·Elisa Torre
Jul 12, 2018·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·Tianxiang GengQunhua Jin
Sep 9, 2017·Critical Reviews in Biotechnology·Julien BarthesNihal Engin Vrana

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