Inhibitory effects of methanolic extract from corydalis tuber against types I-IV allergic models

Biological & Pharmaceutical Bulletin
H MatsudaM Kubo

Abstract

Methanolic extract (CM-ext) from tubers of Corydalis turtschaninovii forma yanhusuo has been screened for activity in experimental models of types I-IV allergy. In type I allergic models, CM-ext at doses of 200, 500 mg/kg, p.o. inhibited 48-h homologous passive cutaneous anaphylaxis (PCA) in rats which is related to IgE, and 4-h heterologous PCA in guinea pigs which is related to IgG. The inhibition of CM-ext on 48-h PCA was also recognized in adrenalectomized rats. CM-ext exhibited the inhibitory effect on formation of IgE antibody in BALB/c mice. In type II allergic model, it was found that CM-ext inhibits reversed cutaneous anaphylaxis (RCA). In type III allergic model, CM-ext showed the inhibitory effect on direct passive arthus reaction (DPAR) in rats. Furthermore, in type IV allergic model, CM-ext had the inhibitory effects on induction phase and effector phase in picryl chloride-induced contact dermatitis (PC-CD). It also showed therapeutic action on PC-CD. These results indicated that CM-ext not only inhibits antibody-mediated allergic reactions but also influences cell-mediated allergic reactions and should be recognized as a potent material for allergic reactions, although the mechanisms and active principles of CM-ex...Continue Reading

Citations

Jul 29, 2010·Redox Report : Communications in Free Radical Research·Bhavani S ShankarKrishna B Sainis
Jan 15, 2014·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Ji Won JungHee Eun Kang
Nov 29, 2014·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Ji Won JungHee Eun Kang
Oct 2, 2001·The Journal of Pharmacy and Pharmacology·J Y ChoM H Park
May 21, 2011·The American Journal of Chinese Medicine·Zengtao XuYitao Wang
Dec 14, 2017·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Liwei ChaiFeng Qiu

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