Inhibitory effects of methylxanthines on the pre-eclamptic-like symptoms in ewes

European Journal of Obstetrics, Gynecology, and Reproductive Biology
G TálosiS Pintér

Abstract

Our objective was to determine whether two methylxanthines, pentoxifylline (PTX) and allopurinol, would have beneficial effects on experimental pregnancy-induced pre-eclampsia- like disease in ewes. 20 animals at the gestational age of 130-135 days were divided into four groups (control; fasting; fasting, pentoxifylline-treated; and fasting, allopurinol-treated). The illness was provoked with a 4-day fasting period. Electrolytes, glucose, conventional parameters, plasma haem content, indirect bilirubin concentration and free thiol levels were measured. Unlike in the fasting group, conventional signs of the disease, such as hypertension, kidney and liver injury and platelet count decrease, were all mitigated in the fasting, drug-treated animals. In the treated animals plasma haem content increased by a less significant level, while indirect bilirubin concentration showed a more rapid rise. Both methylxanthines partly inhibited the pre-eclamptic-like symptoms in ewes. We speculate that the better induction of haem oxygenase might play an important role in this inhibitory effect on this particular animal model.

References

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Citations

Jan 1, 2011·Polish Journal of Veterinary Sciences·P SkopińskiA K Siwicki
Jan 22, 2005·Seminars in Nephrology·Chun LamS Ananth Karumanchi
Jul 15, 2015·Medical Hypotheses·Arsalan AzimiMohammad Mahdi Sagheb

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