Inhibitory effects of naphthols on the activity of mushroom tyrosinase

International Journal of Biological Macromolecules
Yi-Fen LinHe-Tong Lin

Abstract

Tyrosinase (EC 1.14.18.1), a copper-containing multifunctional oxidase, was known to be a key enzyme for biosynthesis in fungi, plants and animals. In this work, the inhibition properties α-naphthol and β-naphthol toward the activity of tyrosinase have been evaluated, and the effects of α-naphthol and β-naphthol on monophenolase and diphenolase activity of tyrosinase have been investigated. The results showed that both α-naphthol and β-naphthol could potently inhibit both monophenolase activity and diphenolase activity of mushroom tyrosinase, and that β-naphthol exhibited stronger inhibitory effect against tyrosinase than α-naphthol. For monophenolase activity, β-naphthol could not only lengthen the lag time but also decrease the steady-state activity, while α-naphthol just only decreased the steady-state activity. For diphenolase activity, both α-naphthol and β-naphthol displayed revisible inhibition. Kinetic analyses showed that both α-naphthol and β-naphthol were competetive inhibitors.

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Citations

Dec 10, 2013·Bioscience, Biotechnology, and Biochemistry·Mary of the Sea García-MolinaFrancis García-Cánovas
Oct 12, 2012·Fitoterapia·Xiaofang WuZhiyong Xie
Jul 19, 2015·Journal of Bioscience and Bioengineering·Amrita AnantharamanRamamoorthy Siva
Mar 8, 2013·International Journal of Biological Macromolecules·Wei-Ming ChaiQing-Xi Chen
Feb 9, 2019·Journal of Enzyme Inhibition and Medicinal Chemistry·Samaneh ZolghadriAli Akbar Saboury

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