PMID: 9182076Jan 1, 1997Paper

Inhibitory effects of okadaic acid on rat uterine contractile responses to different spasmogens

Fundamental & Clinical Pharmacology
M E ArtecheJ D Martín

Abstract

In the present study, we examined the effects of okadaic acid, a selective inhibitor of type 1 and 2A protein phosphatases, on the mechanical responses evoked by oxytocin, K(+)- and Na(+)-modified solutions and ouabain in estrogen-primed rat myometrium. Oxytocin elicited a rapid, phasic contraction followed by rhythmic oscillations. The phasic response was partially resistant to the absence of external Ca2+. Okadaic acid (1 microM) and the L-type calcium channel blocker nifedipine (1 microM) abolished the oscillatory component and reduced the initial, phasic response to about 80% of the control response. High K+ (60 mM) solution, ouabain (1 mM), K(+)-free medium and low Na+ (25 mM) solution induced extracellular Ca(2+)-dependent biphasic responses composed by an early rapid (KCl, ouabain and K(+)-free solution) or slower developed (25 mM Na+ solution) phasic contraction followed by a sustained increase in tension. Okadaic acid and nifedipine, alone or in combination, abolished or decreased similarly the contractile response evoked by these stimulants. The okadaic acid- and nifedipine-insensitive responses to ouabain, K(+)-free and low Na+ solution were enhanced by increasing the extracellular concentration of Ca2+ in the medium...Continue Reading

References

Sep 4, 1992·European Journal of Pharmacology·M L CandenasJ D Martín
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Citations

Jul 19, 2005·Journal of Mammary Gland Biology and Neoplasia·Ronald L HorstTimothy A Reinhardt
Nov 12, 2005·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Stéphane OstrowskiHelga Sauerwein
Jun 23, 2009·Veterinary Research Communications·F PetazziE Pieragostini
Apr 12, 2014·American Journal of Primatology·Kimberley A PhillipsMary Lou Voytko
Jan 18, 2013·American Journal of Physiology. Cell Physiology·Trent ButlerEng-Cheng Chan

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