Inhibitory effects of phenolic compounds on development of naturally occurring preneoplastic hepatocytic foci in long-term feeding studies using male F344 rats

Teratogenesis, Carcinogenesis, and Mutagenesis
A HagiwaraN Ito

Abstract

Five phenolic compounds, namely caffeic acid, sesamol, hydroquinone, catechol, and 4-methoxyphenol, were fed to groups of 30 male F344 rats at dietary levels of 2, 2, 0.3, 0.8, and 2%, respectively, for 2 years. Retardation of body weight and elevated relative liver weights were noted for all groups. Formalin-fixed and paraffin-embedded liver tissues from rats killed terminally were cut and stained for glutathione S-transferase placental form (GST-P) and tumor growth factor alpha (TGF alpha) immunohistochemically. Numbers and areas of GST-P-positive (GST-P+) foci per unit area of liver section were measured, and the respective treated/control proportional values were calculated to be 58 and 57% for caffeic acid. 58 and 54% for sesamol, 71 and 71% for hydroquinone. 58 and 133% for catechol, and 49 and 39% for 4-methoxyphenol. These data were comparable with results obtained with medium-term liver bioassays (Ito test). However, no intergroup differences were detected with regard to quantitative findings for TGF alpha foci, which were relatively rare. Long-term inhibitory effects of phenolic compounds on liver carcinogenesis, predicted from the Ito test, were thus confirmed in the present feeding studies using quantitative analysi...Continue Reading

Citations

Aug 12, 2003·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Vibeke M BreinholtLars O Dragsted
Dec 31, 1998·Free Radical Biology & Medicine·M NardiniC Scaccini
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Apr 24, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Dimitrios StagosDimitrios Kouretas
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Jun 24, 1999·Critical Reviews in Toxicology·A P DeCaprio
May 13, 1999·Teratogenesis, Carcinogenesis, and Mutagenesis·A HagiwaraS Fukushima
Jul 25, 2018·Nutrients·Michele Dei Cas, Riccardo Ghidoni
Jul 30, 2002·Prostaglandins, Leukotrienes, and Essential Fatty Acids·G MamalakisA Kranidis

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