Inhibitory effects of piceatannol on human cytomegalovirus (hCMV) in vitro.

The Journal of Microbiology
San-Ying WangGen-Xiang Mao

Abstract

Human cytomegalovirus (hCMV) is a ubiquitous herpesvirus, which results in the establishment of a latent infection that persists throughout the life of the host and can be reactivated when the immunity is low. Currently, there is no vaccine for hCMV infection, and the licensed antiviral drugs mainly target the viral enzymes and have obvious adverse reactions. Thus, it is important to search for compounds with anti-hCMV properties. The present study aimed to investigate the suppressive effects of piceatannol on hCMV Towne strain infection and the putative underlying mechanisms using human diploid fibroblast WI-38 cells. Piceatannol supplementation prevented the lytic changes induced by hCMV infection in WI-38 cells. Furthermore, piceatannol suppressed the expression of hCMV immediate-early (IE) and early (E) proteins as well as the replication of hCMV DNA in a dose-dependent manner. Moreover, hCMV-induced cellular senescence was suppressed by piceatannol, as shown by a decline in the senescence-associated β-galactosidase (SA-β-Gal) activity and decreased production of intracellular reactive oxygen species (ROS). p16INK4a, a major senescence-associated molecule, was dramatically elevated by current hCMV infection that was attenua...Continue Reading

References

Aug 1, 1975·Journal of Virology·E S Huang
Oct 1, 1983·Antimicrobial Agents and Chemotherapy·E C MarE S Huang
Nov 23, 2000·Nature·T Finkel, N J Holbrook
Jan 10, 2002·Frontiers in Bioscience : a Journal and Virtual Library·Robert F Kalejta, Thomas Shenk
Nov 5, 2002·Journal of Virology·Emanuela NorisSanto Landolfo
May 28, 2003·Journal of Virology·Scott G HansenScott W Wong
Jun 3, 2004·Human Immunology·Elio CastagnolaGiorgio Dini
Jun 13, 2006·Antiviral Research·Karen K Biron
Oct 26, 2007·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Scott D GrosseSheila C Dollard
Dec 20, 2007·Transplantation Proceedings·L GaoS Zheng
Jun 22, 2010·Reviews in Medical Virology·Michael J CannonTerri B Hyde
Jul 21, 2010·Reviews in Medical Virology·Terri B HydeMichael J Cannon
Jan 29, 2011·The Journal of General Virology·Kyosuke KanaiNaoki Inoue
Sep 23, 2011·Journal of Virology·Carisa TiltonJames C Alwine
Nov 28, 2012·Science·Noam Stern-GinossarJonathan S Weissman
Dec 19, 2012·Biochemical and Biophysical Research Communications·Yosuke KinoshitaTatsuhiko Ito
May 8, 2013·Biological & Pharmaceutical Bulletin·Hiroko Maruki-UchidaTatsuhiko Ito
Sep 18, 2013·Cancer Letters·Ella J Ariza-HerediaRoy F Chemaly
Oct 20, 2015·Reviews in Medical Virology·Tao YangJianzhong Cao
Jan 14, 2016·Journal of Agricultural and Food Chemistry·Mohamed Ali SeyedKavitha Vijayaraghavan
Sep 28, 2016·Advances in Experimental Medicine and Biology·Young-Joon Surh, Hye-Kyung Na
Nov 25, 2016·Drugs·K M AnderholmM R Schleiss

❮ Previous
Next ❯

Citations

Jun 8, 2021·South African Journal of Botany : Official Journal of the South African Association of Botanists = Suid-Afrikaanse Tydskrif Vir Plantkunde : Amptelike Tydskrif Van Die Suid-Afrikaanse Genootskap Van Plantkundiges·Marwa ElsbaeyAbdullah A Elgazar

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Related Papers

La Revue de médecine interne
P WattréP E Lobert
Kidney International. Supplement
J G SissonsL K Borysiewicz
Human Vaccines & Immunotherapeutics
Xinle Cui, Clifford M Snapper
Ceská a slovenská oftalmologie : casopis Ceské oftalmologické spolecnosti a Slovenské oftalmologické spolecnosti
K Gergelyová
© 2022 Meta ULC. All rights reserved