Inhibitory effects of prior low-dose X-irradiation on cold-induced brain injury in mouse

Masaaki YoshimotoKiyonori Yamaoka


We examined the inhibitory effects of low-dose X-irradiation on mouse brain tissue with cold-induced injury by comparing tissue samples from three groups of mice: control, sham-irradiated cold-exposed, and X-ray-irradiated (0.5 Gy) cold-exposed mice. The water content in brain increased significantly in the sham-irradiated group following the cold-induced injury relative to the control group. However, water content in brain tissue from the X-ray-irradiated group was significantly lower than that from the sham-irradiated group. Levels of antioxidants, such as superoxide dismutase and glutathione, in brain tissue from the X-ray-irradiated group were higher than those from the sham-irradiated group. Moreover, the cold injury-induced cell death, particularly apoptosis, while low-dose irradiation inhibited cell death, especially among glial cells, but not numeral cells. These findings suggest that prior low-dose X-irradiation activated antioxidant function and inhibited cold-induced brain injury.


Feb 1, 2013·Mediators of Inflammation·Yuichi NishiyamaKiyonori Yamaoka
Dec 6, 2012·Mediators of Inflammation·Teruaki ToyotaKiyonori Yamaoka
Jul 24, 2008·Journal of Clinical Biochemistry and Nutrition·Shinya NakagawaKiyonori Yamaoka
Jun 19, 2016·Regulatory Toxicology and Pharmacology : RTP·Amandeep KaurD K Dhawan
Aug 22, 2016·Redox Biology·Calina BetlazarGuo-Jun Liu
Aug 28, 2016·Radiation and Environmental Biophysics·Engy Refaat RashedMona A El-Ghazaly
Jan 10, 2017·International Journal of Radiation Biology·Eman E ShibryaSanaa A Kenawy
May 6, 2014·Inflammation·Takahiro KataokaKiyonori Yamaoka
Dec 2, 2019·Environmental Science and Pollution Research International·Mona Abd El-Latif El-GhazalyAmina Salem Attia
Apr 30, 2020·Journal of Radiation Research·Takahiro KataokaKiyonori Yamaoka


Sep 1, 1975·The Journal of Clinical Investigation·R L BaehnerR B Johnston
Oct 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·J MårtenssonA Meister
Mar 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·A JainA Meister
Apr 1, 1988·Stroke; a Journal of Cerebral Circulation·K AbeK Kogure
May 31, 1996·Science·M Barinaga
Jun 21, 1996·Science·M Barinaga
Jun 1, 1997·Biological & Pharmaceutical Bulletin·S KojimaA Kubodera
Mar 30, 1999·Progress in Neurobiology·K MurakamiP H Chan
Nov 4, 2000·Journal of Neurotrauma·A LewénP H Chan
Jan 10, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·P H Chan
Sep 1, 1961·Circulation Research·W H KEMPINSKYP P MORGAN
Oct 12, 2007·Journal of Radiation Research·Takahiro KataokaKiyonori Yamaoka
Oct 2, 2009·Journal of Clinical Biochemistry and Nutrition·Takahiro KataokaKiyonori Yamaoka

Related Concepts

Brain Injuries
Mild Traumatic Brain Injury
Salicylhydroxamic acid
Apoptosis, Intrinsic Pathway
Mice, Inbred BALB C
Cold Temperature
Plain X-ray
Antioxidant Effect

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.


Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis