Inhibitory effects of recombinant IL-4 and recombinant IL-13 on UHMWPE-induced bone destruction in the murine air pouch model

The Journal of Surgical Research
Yang WangZhong-Liang Deng

Abstract

We administered recombinant interleukin (IL)-4 and recombinant IL-13 locally into the air pouch of mice to improve bone resorption induced by ultra-high-molecular-weight polyethylene (UHMWPE) particles. Air pouches were established on the back of BALB/c mice, followed by the surgical introduction of a section of calvaria from a syngeneic mouse donor. We stimulated the bone-implanted pouches with the UHMWPE suspension. We divided UHMWPE-containing mice into four study groups to receive injections of phosphate-buffered saline (control), IL-4 alone, IL-13 alone, or IL-4 and IL-13 into the pouches. We harvested the tissues at 14 d after treatment for molecular and histological analyses. The inhibitory effect of IL-4 was stronger than that of IL-13 toward osteoclast differentiation and osteoblast for the induction of osteoprotegerin production and down-regulation of receptor for activation of nuclear factor-κB ligand production. Furthermore, the combined treatment with both IL-4 and 1L-13 had a more important role in inhibiting bone resorption in these pouches with UHMWPE stimulation, compared with IL-4 or IL-13 treatment alone. Local administration of recombinant IL-4 and IL-13 may be a feasible and effective therapeutic candidate ...Continue Reading

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Citations

May 31, 2015·Advanced Drug Delivery Reviews·Siew-Min OngSiew-Cheng Wong
Aug 27, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Eric R MolinaAntonios G Mikos
Jan 23, 2014·International Forum of Allergy & Rhinology·Kornkiat SnidvongsRichard J Harvey
Jul 22, 2014·Journal of Biomedical Materials Research. Part a·Jukka PajarinenStuart B Goodman
Oct 20, 2018·Journal of Cellular Biochemistry·Tingshuai Zhang, Yongchang Yao
Jul 6, 2014·Clinical Orthopaedics and Related Research·R Lane Smith, Edward M Schwarz
Mar 16, 2019·Current Allergy and Asthma Reports·Kornkiat SnidvongsRichard J Harvey
Dec 7, 2019·Journal of Clinical Medicine·Stuart B Goodman, Jiri Gallo
Feb 6, 2020·Allergy, Asthma & Immunology Research·Roza KhalmuratovaHyun Woo Shin
Dec 30, 2020·Oral Diseases·Minting Wu, Jing Liu
Jun 15, 2021·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Ericka P von KaepplerWilliam H Robinson

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