Abstract
We administered recombinant interleukin (IL)-4 and recombinant IL-13 locally into the air pouch of mice to improve bone resorption induced by ultra-high-molecular-weight polyethylene (UHMWPE) particles. Air pouches were established on the back of BALB/c mice, followed by the surgical introduction of a section of calvaria from a syngeneic mouse donor. We stimulated the bone-implanted pouches with the UHMWPE suspension. We divided UHMWPE-containing mice into four study groups to receive injections of phosphate-buffered saline (control), IL-4 alone, IL-13 alone, or IL-4 and IL-13 into the pouches. We harvested the tissues at 14 d after treatment for molecular and histological analyses. The inhibitory effect of IL-4 was stronger than that of IL-13 toward osteoclast differentiation and osteoblast for the induction of osteoprotegerin production and down-regulation of receptor for activation of nuclear factor-κB ligand production. Furthermore, the combined treatment with both IL-4 and 1L-13 had a more important role in inhibiting bone resorption in these pouches with UHMWPE stimulation, compared with IL-4 or IL-13 treatment alone. Local administration of recombinant IL-4 and IL-13 may be a feasible and effective therapeutic candidate ...Continue Reading
References
Jan 1, 1994·Scandinavian Journal of Rheumatology. Supplement·G W Duff
Mar 1, 1995·Annals of the Rheumatic Diseases·N al-SaffarP A Revell
Jun 1, 1995·Endocrinology·D L LaceyA Shioi
Jun 9, 1995·The Journal of Biological Chemistry·S M ZurawskiG Zurawski
Jan 1, 1994·Immunology Today·G Zurawski, J E de Vries
Dec 1, 1993·Journal of Cellular Biochemistry·G R Mundy
Apr 29, 1998·Bone·Y OkadaS Eto
Dec 18, 1998·Science·G GrünigD B Corry
Aug 4, 1999·The Journal of Experimental Medicine·S NiidaH Kodama
May 17, 2000·FEBS Letters·M NakagawaY Hakeda
Aug 2, 2000·The EMBO Journal·I N HolcombC C Hébert
Jun 8, 2001·The Journal of Clinical Investigation·Y Abu-Amer
Nov 15, 2001·Journal of Dental Research·M KakuK Tanne
Oct 2, 2002·Arthritis and Rheumatism·Shang-You YangPaul H Wooley
Apr 12, 2003·Blood·Jose L MorenoMehrdad Tondravi
Sep 13, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Keita MiyanishiR Lane Smith
Oct 30, 2004·Scandinavian Journal of Rheumatology·W RenP H Wooley
Mar 9, 2005·Biochemical and Biophysical Research Communications·Saad Gad Kamel MohamedMasashi Kobayashi
Jul 28, 2005·The Journal of Biological Chemistry·Yoonji KimHiroshi Takayanagi
Jul 4, 2006·Biomaterials·Wei Ping RenPaul H Wooley
Mar 9, 2007·Immunology·Atsushi YamadaRyutaro Kamijo
Dec 26, 2008·Science Signaling·Marsha Wills-Karp, Fred D Finkelman
Mar 6, 2009·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·David C MarkelWeiping Ren
Oct 20, 2010·European Respiratory Review : an Official Journal of the European Respiratory Society·C K OhN Molfino
Citations
May 31, 2015·Advanced Drug Delivery Reviews·Siew-Min OngSiew-Cheng Wong
Aug 27, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Eric R MolinaAntonios G Mikos
Jan 23, 2014·International Forum of Allergy & Rhinology·Kornkiat SnidvongsRichard J Harvey
Nov 28, 2013·Microscopy Research and Technique·Daniela F Duarte CamposHorst Fischer
Jul 22, 2014·Journal of Biomedical Materials Research. Part a·Jukka PajarinenStuart B Goodman
Jan 31, 2014·Journal of the Royal Society, Interface·S B GoodmanY T Konttinen
Oct 20, 2018·Journal of Cellular Biochemistry·Tingshuai Zhang, Yongchang Yao
Jul 6, 2014·Clinical Orthopaedics and Related Research·R Lane Smith, Edward M Schwarz
Feb 16, 2017·Frontiers in Immunology·Bin LiXianlong Zhang
Mar 16, 2019·Current Allergy and Asthma Reports·Kornkiat SnidvongsRichard J Harvey
Dec 7, 2019·Journal of Clinical Medicine·Stuart B Goodman, Jiri Gallo
Feb 6, 2020·Allergy, Asthma & Immunology Research·Roza KhalmuratovaHyun Woo Shin
Dec 30, 2020·Oral Diseases·Minting Wu, Jing Liu
Jun 4, 2021·Frontiers in Immunology·Liangliang WangDechun Geng
Jun 15, 2021·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Ericka P von KaepplerWilliam H Robinson