Inhibitory effects of Saururus chinensis and its components on stomach cancer cells

Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
Ha Jin JeongSonghee Jeon

Abstract

Saururus chinensis (SC) Baill. (Saururaceae), a perennial herb commonly called Chinese lizard's tail or Sam-baekcho in Korea, has been used in the treatment of edema, gonorrhea, jaundice, and inflammatory diseases. Recently, several reports have been commissioned to examine the anti-cancer activities of this plant. In this study, we evaluated the inhibitory activity and mechanism of action on SC and its components against stomach cancer cells. SC extracts displayed cytotoxic effects on AGS cells in a dose-dependent manner. Moreover, SC increased the number of annexin V-positive apoptotic bodies and phosphorylated JNK and p38 in AGS cells. SC also down-regulated anti-apoptotic (Bcl-2) genes and up-regulated apoptotic (Bax) genes in AGS cells. We further confirmed that caspase activation plays an important role in SC-induced apoptosis in AGS cells. Furthermore, we examined erythro-Austrobailignan-6 and meso-dihydroguaiaretic acid, major active constituents of SC, which induced apoptosis in both the AGS and NCI-N87 stomach cancer cell lines. Taken together, our data provide the evidence that SC and its components induce apoptosis in stomach cancer cells, making it a potential candidate as a chemotherapeutic drug.

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Citations

Mar 2, 2016·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Lijuan ZhaoDongmei Ren
Jan 17, 2016·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Jae-Young LeeHyun-Jong Cho
Feb 10, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Byoung Hoon YouYoung Hee Choi
Jan 23, 2020·The American Journal of Chinese Medicine·Guangxin LiuCuiqin Li

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