Inhibitory effects of seven components of danshen extract on catalytic activity of cytochrome P450 enzyme in human liver microsomes

Drug Metabolism and Disposition : the Biological Fate of Chemicals
Furong QiuGuangji Wang

Abstract

The potential for herb-drug interactions has recently received greater attention worldwide, considering the fact that the use of herbal products becomes more and more widespread. The goal of this work was to examine the potential for the metabolism-based drug interaction arising from seven active components (danshensu, protocatechuic aldehyde, protocatechuic acid, salvianolic acid B, tanshinone I, tanshinone IIA, and cryptotanshinone) of danshen extract. Probe substrates of cytochrome P450 enzymes were incubated in human liver microsomes (HLMs) with or without each component of danshen extract. IC(50) and K(i) values were estimated, and the types of inhibition were determined. Among the seven components of danshen extract, tanshinone I, tanshinone IIA, and cryptotanshinone were potent competitive inhibitors of CYP1A2 (K(i) = 0.48, 1.0, and 0.45 microM, respectively); danshensu was a competitive inhibitor of CYP2C9 (K(i) = 35 microM), and cryptotanshinone was a moderate mixed-type inhibitor of CYP2C9 (K(i) = 8 microM); cryptotanshinone inhibited weakly and in mixed mode against CYP2D6 activity (K(i) = 68 microM), and tanshinone I was a weak inhibitor of CYP2D6 (IC(50) = 120 microM); and protocatechuic aldehyde was a weak inhibit...Continue Reading

References

Apr 1, 1997·Journal of Internal Medicine·C M YuJ E Sanderson
Jul 15, 1998·British Journal of Clinical Pharmacology·J O Miners, D J Birkett
Sep 2, 1998·British Journal of Clinical Pharmacology·D G BaileyJ D Spence
Apr 17, 2001·The Annals of Pharmacotherapy·T Y Chan
Jan 17, 2002·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Jasminder SahiV Hayden Thomas
Oct 31, 2002·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·J David Spence
Nov 16, 2002·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Rae YuanShiew-Mei Huang
Dec 18, 2002·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Monica I JushchyshynPaul F Hollenberg
Jul 10, 2003·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Yune-Fang UengYun-Lian Lin
May 25, 2004·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Robert L Walsky, R Scott Obach
Sep 3, 2004·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Hiroshi IwataTadashi Watabe
Jul 29, 2005·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Anthony AtkinsonKen Grime
Jan 18, 2006·Journal of Ethnopharmacology· SubehanYasuhiro Tezuka
Feb 7, 2006·Journal of Pharmaceutical and Biomedical Analysis·Limin ZhouZhong Zuo
Mar 21, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·Yong LiuLing Yang
Apr 7, 2006·The Journal of Pharmacy and Pharmacology·Ya-Hui KuoYune-Fang Ueng
Nov 10, 2006·Drug Metabolism and Disposition : the Biological Fate of Chemicals·R Scott ObachKarthik Venkatakrishnan
Mar 17, 2007·International Journal of Cardiology·Tsung O Cheng
Oct 27, 2007·British Journal of Clinical Pharmacology·Furong QiuJian Sun

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Citations

Jul 26, 2011·Evidence-based Complementary and Alternative Medicine : ECAM·Xiao-Long HouKoichi Takahashi
Jan 5, 2014·BMC Complementary and Alternative Medicine·Sixun GuoGaofeng Liu
Nov 14, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Furong QiuPing Miao
Nov 30, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jiawang LiuMaryam Foroozesh
Apr 24, 2009·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·H-X LiuL Yang
Jun 19, 2009·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Y ChenH-H Zhou
May 1, 2012·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Xuelin ZhouJohn H K Yeung
Sep 9, 2011·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Wayne Y W LeeJohn H K Yeung
Jul 20, 2010·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Xin WangJohn H K Yeung
Mar 23, 2011·Phytotherapy Research : PTR·Xin Wang, John H K Yeung
Jan 10, 2012·Phytotherapy Research : PTR·Tun-Yu JianGui-Li Xu
Jun 8, 2010·Basic & Clinical Pharmacology & Toxicology·Fang YuanMin Huang
Jun 23, 2010·British Journal of Clinical Pharmacology·Furong QiuYueming Ma
Sep 10, 2014·Phytotherapy Research : PTR·Himanshu Rastogi, Snehasis Jana
Jan 26, 2011·Toxicology and Applied Pharmacology·Rong ZhangGuangji Wang
Jul 22, 2011·Atherosclerosis·Si GaoSuowen Xu
Oct 6, 2011·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Li-Ping YangShu-Feng Zhou
Nov 8, 2011·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Xin Wang, John Hok-Keung Yeung
Jan 30, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Songcan LiuJian Jiang
Oct 14, 2016·European Journal of Drug Metabolism and Pharmacokinetics·Khaled S AbdelkawyFawzy Elbarbry
Apr 2, 2017·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Xianhua ZhangXinliang Ma
May 12, 2011·Journal of Cardiovascular Pharmacology·Hiu-Ting ChanHung-Fat Tse
Dec 20, 2012·Expert Review of Molecular Diagnostics·Miao HuBrian Tomlinson
Jan 24, 2012·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Yuan XieHaiping Hao
Apr 3, 2020·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Hui HeChao Yu

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