Inhibitory effects of several saturated fatty acids and their related fatty alcohols on the growth of Candida albicans

Drug Discoveries & Therapeutics
Kazumi HayamaShigeru Abe

Abstract

We examined the effect of 5 saturated fatty acids and their related alcohols on the growth of Candida albicans. The inhibitory effects of these compounds against the yeast and hyphal growth forms of C. albicans were examined using the modified NCCLS method and crystal violet staining, respectively. Among these compounds, capric acid inhibited both types of growth at the lowest concentration. The IC(80), i.e., the concentration at which the compounds reduced the growth of C. albicans by 80% in comparison with the growth of control cells, of capric acid for the hyphal growth of this fungus, which is indispensable for its mucosal invasion, was 16.7 μM. These fatty acids, including capric acid, have an unpleasant smell, which may limit their therapeutic use. To test them at reduced concentrations, the combined effect of these fatty acids and oligonol, a depolymerized polyphenol, was evaluated in vitro. These combinations showed potent synergistic inhibition of hyphal growth [fractional inhibitory concentration (FIC) index = 0.319]. Our results demonstrated that capric acid combined with oligonol could be used as an effective anti-Candida compound. It may be a candidate prophylactic or therapeutic tool against mucosal Candida infect...Continue Reading

References

Mar 1, 1993·The British Journal of Nutrition·E GuillotA Rérat
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May 7, 2009·Oral Microbiology and Immunology·A Dongari-BagtzoglouJ Burleson
Aug 19, 2010·Nihon Ishinkin Gakkai zasshi = Japanese journal of medical mycology·Kazumi HayamaShigeru Abe
Jan 1, 2014·Medical Mycology Journal·Yuuki Taguchi

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Citations

Jun 6, 2020·Pharmaceutics·Jake G EdmansHelen E Colley
Oct 5, 2019·Journal of the Indian Society of Pedodontics and Preventive Dentistry·Krishnapriya DevanK Rahul Suresh

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