Inhibitory effects of tea extracts and (-)-epigallocatechin gallate on DNA synthesis and proliferation of hepatoma and erythroleukemia cells

Cancer Letters
M A LeaC S Yang

Abstract

Polyphenols extracted from green or black tea with ethyl acetate were strongly inhibitory for DNA synthesis in HTC rat hepatoma cells and DS19 mouse erythroleukemia cells at concentrations of 0.1-0.2 mg/ml. There was less inhibition with a subsequent black tea fraction extracted with butanol and with the residual water-soluble fraction. Although cell proliferation was inhibited by (-)-epigallocatechin gallate and the tea extracts, there were only marginal effects on differentiation of DS19 cells as judged by hemoglobin synthesis.

References

Jul 11, 1992·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·L L SpriggsJ R Jeter
May 1, 1992·Preventive Medicine·H MukhtarR Agarwal
May 1, 1992·Preventive Medicine·H HayatsuI Sakata
Jan 1, 1990·Chemico-biological Interactions·M A LeaS Ayyala
Jul 1, 1966·Proceedings of the National Academy of Sciences of the United States of America·E B ThompsonJ F Curran

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Citations

Oct 8, 2003·BioFactors·Hironori TsuchiyaHiroshi Takeuchi
Oct 2, 2003·Journal of Chromatography. a·David J Weiss, Christopher R Anderton
Jan 1, 1997·Free Radical Biology & Medicine·P LeandersonC Tagesson
Jan 25, 2006·Critical Reviews in Food Science and Nutrition·Sailendra N NichenametlaJerry H Exon
Apr 29, 2009·Critical Reviews in Food Science and Nutrition·Vasundhara Sharma, L Jagan Mohan Rao
Mar 7, 2003·Mutagenesis·Fenton CatterallCostas Ioannides
Nov 15, 2008·Journal of Cellular Biochemistry·Jae-Hoon JeongYong J Lee
Oct 7, 2004·European Journal of Pharmacology·Marcel W L Koo, Chi H Cho
Nov 7, 2006·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·F KhalloukiR W Owen
Nov 13, 2015·Critical Reviews in Food Science and Nutrition·Brahma N SinghB R Singh
Jan 5, 2002·Drug Metabolism Reviews·C S YangJ Landau
Mar 29, 2014·Chemical Reviews·Madhu AeluriPrabhat Arya
Feb 7, 2006·Free Radical Biology & Medicine·Giuseppe GalatiPeter J O'Brien
Dec 17, 2008·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Christopher D MannDavid P Berry
Oct 14, 2006·Molecular Nutrition & Food Research·Chin-Lin Hsu, Gow-Chin Yen
Feb 17, 2005·The Journal of Biological Chemistry·Svetlana ErmakovaZigang Dong
Jun 18, 2003·The Journal of Biological Chemistry·Tatiana EfimovaRichard L Eckert
Dec 24, 2015·ChemMedChem·Andrew M Beekman, Lesley A Howell
Sep 9, 1999·The American Journal of Clinical Nutrition·W J Craig
Sep 19, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Tomonori NakazatoMasahiro Kizaki
Apr 15, 2004·Archives of Biochemistry and Biophysics·Claudia KeilShiao Li Oei

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