Inhibitory effects of tea polyphenols by targeting cyclooxygenase-2 through regulation of nuclear factor kappa B, Akt and p53 in rat mammary tumors.

Investigational New Drugs
Preeti RoyYogeshwer Shukla

Abstract

Breast cancer has become the second leading cause of cancer-related deaths worldwide. The control of this disease can be achieved through chemoprevention, which refers to the consumption of synthetic or naturally occurring agents to block, reverse, or delay the process of tumor development. Tea (Camellia sinensis), the most widely consumed beverage, has shown promises in the field of cancer chemoprevention. Inhibition of tumorigenesis by green or black tea polyphenols has been demonstrated in various in vitro and in vivo models. Here, we examined the inhibitory effect of green tea polyphenol (GTP) and black tea polyphenol (BTP) on the development of mammary tumors- induced by 7, 12-dimethylbenz (a) anthracene (DMBA) in female, Wistar rats. 13% and 33% of animals developed tumors in GTP and BTP supplemented groups, respectively. Both GTP and BTP are effective in significantly inhibiting the cumulative number of mammary tumors (by ~92% and 77%, respectively) and in reducing their growth. Mechanistically, we investigated the effects of GTP and BTP on the components of cell signaling pathways, connecting biomolecules involved in cancer development. GTP and BTP supplementation as a sole source of drinking solution leads to scavengin...Continue Reading

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Citations

May 30, 2013·International Journal of Nanomedicine·Amit Kumar SrivastavaKailash Chand Gupta
Dec 29, 2011·Frontiers in Bioscience (Elite Edition)·Jyoti KanwarQing Ping Dou
Apr 10, 2014·Journal of Traditional and Complementary Medicine·Wen-Hsin TsaiChiang-Ting Chien
Oct 2, 2015·Journal of Psychiatric Research·Eran Elhaik, Peter Zandi
Feb 24, 2015·Cell Biochemistry and Biophysics·Ling NiuXin-Jiang An
Dec 5, 2013·Restorative Dentistry & Endodontics·Zahra KhamverdiShiva Rostami
Jul 30, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Abhishek KumarShakti P Pattanayak
Sep 12, 2019·Healthcare·Amani Al ShaikhKaren S Bishop
Mar 16, 2021·Critical Reviews in Oncology/hematology·RamaRao MallaGanji Purnachandra Nagaraju

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