Inhibitory effects of tetrandrine on human neutrophil and monocyte adherence

Immunology Letters
W K SeowY H Thong

Abstract

Tetrandrine is a plant alkaloid useful in the treatment of silicosis. Its mode of action is unknown, but results of the present study show dose-dependent inhibition of human neutrophil and monocyte adherence at concentrations (0.1-10 micrograms/ml) easily achieved in plasma during drug therapy. Monocytes were shown to be more sensitive to tetrandrine than neutrophils. Dye-exclusion experiments indicate that tetrandrine is non-toxic to these cells at 10 micrograms/ml concentrations. Suppression of adherence was reversible by washing, suggesting that the drug does not bind tightly to membrane components. Enhancement of adherence by the tumour promoter, phorbol myristate acetate, was abolished by tetrandrine. The uptake of deoxyglucose by neutrophils and monocytes was suppressed by tetrandrine. These results indicate that tetrandrine may act by interfering with the recruitment of these cells into silicotic lesions.

References

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Citations

Jan 1, 1990·International Journal of Immunopharmacology·B S TehY H Thong
Oct 1, 1992·International Journal of Immunopharmacology·Y KondoS Nozoe
Mar 1, 1994·International Journal of Immunopharmacology·S Y LiY H Thong
Aug 1, 1996·Clinical and Experimental Pharmacology & Physiology·H TakemuraC Y Kwan
Jan 1, 1991·International Journal of Immunopharmacology·C W WongY H Thong
Jul 6, 2014·Journal of Immunology Research·Thaline F A LimaLigia M T Peçanha
Mar 18, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jaime Ribeiro-FilhoPatrícia T Bozza
Sep 3, 2013·Toxicology and Applied Pharmacology·Jaime Ribeiro-FilhoPatrícia T Bozza

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