Inhibitory effects of the Gentiana macrophylla (Gentianaceae) extract on rheumatoid arthritis of rats

Journal of Ethnopharmacology
Farong YuRui Wang

Abstract

Acute treatment of rheumatoid rats with an extract from the roots of Gentiana macrophylla (Gentianaceae) produced a significant inhibitory effect on rheumatoid arthritis (RA). When rats were administered the Gentiana macrophylla extract orally at a daily dose of 100 mg/kg body weight, the prostaglandin E(2) (PGE(2)) levels in the inflammatory tissues, sole thickness, and ankle circumferences of feet were significantly decreased. The anti-inflammatory activity observed in Gentiana macrophylla is comparable to that observed in prednisone. These observations suggest that Gentiana macrophylla displays considerable potency in anti-inflammatory action and could be used as an anti-inflammatory agent in the control of inflammation of rheumatoid arthritis.

References

Jul 1, 1996·Phytochemistry·R X TanK Hostettmann

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Citations

Jun 27, 2009·Archives of Pharmacal Research·Jeong-Ah KimSeung-Ho Lee
Mar 16, 2012·Natural Product Research·Shihu WeiGuang Chen
Apr 9, 2008·Journal of Clinical Biochemistry and Nutrition·Brijesh RathoreSiddharth Kumar Das
Jan 28, 2014·Autoimmunity Reviews·Christopher Chang
Mar 20, 2013·Journal of Ethnopharmacology·Yan-Ming WangYing-Jun Zhang
May 8, 2020·Biological & Pharmaceutical Bulletin·Min YangFu-Sheng Wang
Feb 18, 2016·Chemistry & Biodiversity·Yu PanYuan-Zhong Wang
Dec 19, 2017·Experimental and Therapeutic Medicine·Zengmei LanJun Zhou
May 9, 2014·Journal of Natural Products·Yu-jie HuangLi-jiang Xuan
Dec 1, 2010·Bioorganic & Medicinal Chemistry·Shivaprasad H VenkateshaKamal D Moudgil

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