PMID: 9187566Apr 1, 1997Paper

Inhibitory effects of theophylline and procaterol on eosinophil function

Internal Medicine
Y OkuboM Sekiguchi

Abstract

Eosinophils play a crucial role in bronchial asthma. As theophylline and procaterol (beta 2-agonist) are used for the treatment of bronchial asthma, the specific functions of eosinophils in the presence of granulocyte/macrophage colony-stimulating factor (GM-CSF) or platelet activating factor (PAF) were examined using theophylline and procaterol alone and in combination. Eosinophil degranulation induced by PAF or GM-CSF was inhibited by theophylline (10(-6) M-10(-3) M and 10(-6) M to 10(-3) M, respectively) and procaterol (10(-7) M-10(-5) M and 10(-7) M-10(-5) M, respectively). The combination of 10(-4) M theophylline and various concentrations of procaterol provided higher inhibition than 10(-4) M theophylline or procaterol (10(-7) M-10(-5) M). CD11b, which is a triggering molecule for human eosinophil degranulation, showed a significantly inhibited expression of PAF stimulation with 10(-4) M theophylline. CD11b and another triggering molecule for eosinophil degranulation, CD18, showed a significantly inhibited expression of PAF stimulation using a combination of 10(-4) M theophylline and various concentrations of procaterol (10(-5) M-10(-7) M) compared with the inhibition of 10(-4) M theophylline or procaterol (10(-5) M-10(-7...Continue Reading

Citations

Jan 25, 2014·Pulmonary Pharmacology & Therapeutics·Yanira Riffo-VasquezClive P Page
Jul 25, 2007·Allergology International : Official Journal of the Japanese Society of Allergology·Chiyohiko ShindohGen Tamura
Jun 10, 2011·International Archives of Allergy and Immunology·Yukiko HiraguchiTakao Fujisawa
Aug 9, 2007·International Archives of Allergy and Immunology·Izumi KikuchiMakoto Nagata
Mar 9, 2002·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Takao FujisawaHitoshi Kamiya
Jul 18, 2001·Journal of Applied Physiology·S TakashiS Horie

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