Inhibitory Effects of Two Varieties of Tunisian Pomegranate (Punica granatum L.) Extracts on Gastrointestinal Transit in Rat

Journal of Medicinal Food
Abdelaziz SouliLamjed Marzouki

Abstract

The present study was undertaken to determine whether total and methanol juice extracts of two Tunisian Pomegranate (Punica granatum L.) varieties (Garsi and Gabsi) protect against diarrhea as well as their effects on gastrointestinal transit (GIT) in healthy rats. In this respect, male Wistar rats were used and divided into control- and pomegranate-treated groups. The antidiarrheal activity was evaluated using the castor oil-induced diarrhea method and the GIT was assessed using charcoal meal. Our results showed that total and methanol P. granatum juice extracts produced a significant dose-dependent protection against castor oil-induced diarrhea. Pomegranate extracts and juice also decreased the GIT significantly and dose dependently. Importantly, the Garsi variety appeared to be more effective than the Gabsi variety on these two parameters. These findings suggest that pomegranate extracts have a potent antidiarrheal property in rats confirming their efficiency in the Tunisian traditional medicine.

References

Jan 1, 1978·The Journal of Pharmacy and Pharmacology·F AwoutersP A Janssen
Jun 26, 1965·Nature·R A PhillipsE M Neptune
Apr 1, 1995·The Journal of Infectious Diseases·A GuarinoA Rubino
Sep 24, 1999·Naunyn-Schmiedeberg's Archives of Pharmacology·A A IzzoF Capasso
Dec 22, 1999·Archives of Internal Medicine·A F Hofmann
May 8, 2000·International Journal of Cancer. Journal International Du Cancer·S FranceschiC La Vecchia
May 11, 2001·Planta medica·S BajadR K Johri
Feb 28, 2002·Fitoterapia·Swati BiswasB P Saha
Mar 30, 2005·Lancet·Jennifer BryceUNKNOWN WHO Child Health Epidemiology Reference Group
Dec 1, 2005·Phytotherapy Research : PTR·Federica VitaliBeatrice Tita
Feb 24, 2009·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·John A O OjewoleWitness D H Chiwororo
Aug 19, 2009·International Journal of Food Sciences and Nutrition·Walid ElfallehAli Ferchichi
Nov 3, 2009·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Suwebatu T Odunsi-ShiyanbadeAlan R Zinsmeister
Jun 17, 2010·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Ahmed KarimMohammed Aziz
Oct 12, 2010·Indian Journal of Dental Research : Official Publication of Indian Society for Dental Research·Mithun B H PaiG N Chandu
Mar 8, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Rafik BachoualJamel El-Benna
May 17, 2011·Journal of Ethnopharmacology·Emmanuel O AweOyindamola O Abiodun
Jul 7, 2011·Journal of Ayurveda and Integrative Medicine·Yasmeen ManiyarN V Agashikar
Aug 19, 2011·Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine·Sachin V Tembhurne, Dinesh M Sakarkar
Sep 10, 2011·The American Journal of Chinese Medicine·Hye Kyung KimHong-Yon Cho
Dec 2, 2011·Annual Review of Food Science and Technology·Suzanne D Johanningsmeier, G Keith Harris
Mar 14, 2012·Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine·Vikas V PatilVijay R Patil
Jul 24, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Christine F Coursodon-BoyiddleBohuslav Dvorak

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Citations

Dec 17, 2015·The Journal of Pharmacy and Pharmacology·Mohamed-Amine JabriHichem Sebai
Apr 9, 2016·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Lei XuFengHua Liu

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