PMID: 18198487Jan 17, 2008Paper

Inhibitory effects of xanthone on paraquat- and NaNO(2)-induced genotoxicity in cultured cells

The Journal of Toxicological Sciences
Reiko Tanaka

Abstract

The inhibitory effects of xanthone on genotoxicity induced by paraquat and NaNO(2) in cultured Chinese hamster lung (CHL) cells were examined. Xanthone forms the central core of xanthones. Xanthones are present in mangosteen, which is widely used as health food because of its many pharmacological properties. Paraquat (PQ, a superoxide anion generator) and NaNO(2) induce genotoxic effects, including sister chromatid exchange (SCE) and decreased cell cycle rate, in CHL cells. Xanthone inhibited the genotoxic effects of PQ and NaNO(2) at concentrations of more than 5 microM. The present results suggested the potent antigenotoxic effects of xanthones in mangosteens.

References

Jan 1, 1982·Toxicology·R S GoldsteinJ T Bond
Aug 1, 1995·Free Radical Research·P WilliamsL Beilin
Feb 24, 2001·Free Radical Research·W MahabusarakamK Croft
Sep 17, 2002·Biological & Pharmaceutical Bulletin·Keigo NakataniYasushi Ohizumi
Jun 5, 2004·Cardiovascular Drug Reviews·De-Jian JiangYuan-Jian Li
Oct 28, 2005·Current Medicinal Chemistry·M M M PintoM S J Nascimento
Jan 1, 1989·Toxicology in Vitro : an International Journal Published in Association with BIBRA·R Tanaka, Y Amano

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