Inhibitory effects of yuzu and its components on human platelet aggregation

Biomolecules & Therapeutics
Tae-Ho KimYi-Sook Jung

Abstract

Our previous study demonstrated that yuzu has an anti-platelet effect in rat blood. In the present study, we examined whether the anti-platelet effect of yuzu can be extended to human blood by investigating its ability to inhibit aggregations induced by various agonists in human platelet rich plasma (PRP). This study also investigated the underlying mechanism of yuzu focusing on ADP granule secretion, TXB2 formations, and PLCγ/Akt signaling. The results from this study showed that ethanolic yuzu extract (YE), and its components, hesperidin and naringin, inhibited human platelet aggregation in a concentration-dependent manner. YE, hesperidin and naringin also inhibited TXB2 formation and ADP release. The phosphorylation of PLCγ and Akt was significantly inhibited by YE, heperidin and naringin. Furthermore, we demonstrated that YE, heperidin and naringin has anti-platelet effects in rat ex vivo studies, and lower side effects in mice tail bleeding time studies. The results from this study suggest that YE, hesperidin and naringin can inhibit human platelet aggregation, at least partly through the inhibition of PLCγ and Akt, leading to a decrease in TXB2 formation and granule secretion.

References

Jun 11, 2002·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Yi-Sook JungChang-Hyun Moon
Jul 24, 2002·Archives of Pharmacal Research·Mi Kyung PyoHye Sook Yun-Choi
Nov 2, 2002·Nature Medicine·Zaverio M Ruggeri
Jul 1, 2008·British Journal of Pharmacology·N E BarrettJ M Gibbins
Mar 1, 2011·Journal of Ethnopharmacology·Eun Ji SeoYi-Sook Jung
Oct 19, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Hye Yon YuYi-Sook Jung
Nov 22, 2011·International Journal of Cardiology·Jean-Pierre Bassand
Oct 3, 2012·Acta Anaesthesiologica Taiwanica : Official Journal of the Taiwan Society of Anesthesiologists·Jiin-Tarng LiouYuan-Ji Day
Oct 19, 2013·Arteriosclerosis, Thrombosis, and Vascular Biology·Sakthivel VaiyapuriJonathan M Gibbins
Jul 2, 2014·Journal of Agricultural and Food Chemistry·Do-Seop LeeYi-Sook Jung

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Citations

Aug 11, 2016·Molecular Nutrition & Food Research·Eun Joo JeonChang Hwa Jung
May 21, 2019·Chemical Biology & Drug Design·Huimin LiHaitao Zhang
Feb 27, 2020·Journal of Cosmetic Dermatology·Julie K NguyenJared Jagdeo
Jun 16, 2018·Experimental and Therapeutic Medicine·Mingxia SunZhenyu Zhang

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Methods Mentioned

BETA
protein assay

Software Mentioned

Sigma Stat

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