Inhibitory interactions of calcineurin (phosphatase 2B) and calmodulin on rat hippocampal NMDA receptors

Neuropharmacology
Beth K Rycroft, Alasdair J Gibb

Abstract

Calcineurin, protein phosphatase 2B, is a calcium-binding protein that has been shown to modulate NMDA receptor activity (Regulation of NMDA channel function by endogenous Ca(2+)-dependent phosphatase. Nature 369 (1994) 235; Regulation of glycine-insensitive desensitisation of the NMDA receptor in outside-out patches. J. Neurophysiol. 71 (1994) 754; Calcineurin acts via the C-terminus of NR2A to modulate desensitization of NMDA receptors. Neuropharmacology 42 (2002) 593) and synaptic transmission (Synaptic desensitization of NMDA receptors by calcineurin. Science 267 (1995) 1510; beta-adrenergic regulation of synaptic NMDA receptors by cAMP-dependent protein kinase. Neuron 16 (1996) 415). Calmodulin, a necessary co-factor for calcineurin (Calmodulin binding by calcineurin. J. Biol. Chem. 262 (1987) 15062), has also been shown to inhibit NMDA receptor activity (Inactivation of NMDA receptors by direct interaction of calmodulin with the NR1 subunit. Cell 84 (1996) 745; Direct effects of calmodulin on NMDA receptor single-channel gating in rat hippocampal granule cells. J. Neurosci. 22 (2002) 8860) in a calcium dependent manner (Calmodulin mediates calcium-dependent inactivation of N-methyl-d-aspartate receptors. Neuron 21 (1998) ...Continue Reading

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Citations

May 29, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Cassandra L KussiusGabriela K Popescu
Dec 3, 2013·European Journal of Pharmacology·Yuriy Pankratov, Ulyana Lalo
Jan 6, 2012·Neurología : publicación oficial de la Sociedad Española de Neurología·M E Flores-SotoC Beas-Zarate
Feb 16, 2011·Seminars in Cell & Developmental Biology·Ulyana LaloYuri Pankratov
Oct 29, 2014·The Journal of General Physiology·Bruce A Maki, Gabriela K Popescu
Jan 26, 2010·Progress in Neurobiology·Andrea ContestabileLaura Gasparini
Jul 25, 2008·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Rodrigo D PazKuei Y Tseng
May 23, 2008·Neuroscience·Y PankratovA Verkhratsky
Apr 28, 2011·Fundamental & Clinical Pharmacology·Linan ZhangYongli Wang
Sep 29, 2011·Molecular and Cellular Endocrinology·Alexei VerkhratskyVladimir Parpura
Apr 8, 2010·Biophysical Journal·Stacy A Amico-Ruvio, Gabriela K Popescu
Dec 3, 2014·Pharmacology, Biochemistry, and Behavior·Milene BorsoiCarlos-Alberto Gonçalves
Jun 18, 2016·Frontiers in Physiology·Paula F KinoshitaCristoforo Scavone
Dec 18, 2013·The Journal of Physiology·Angela R WildAlasdair J Gibb
Jun 8, 2021·Neuropharmacology·Yevheniia IshchenkoAnthony J Koleske

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