PMID: 11912066Mar 26, 2002Paper

Inhibitory mechanism of costunolide, a sesquiterpene lactone isolated from Laurus nobilis, on blood-ethanol elevation in rats: involvement of inhibition of gastric emptying and increase in gastric juice secretion

Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism
H MatsudaM Yoshikawa

Abstract

Basic inhibitory mechanisms of costunolide and its active component, alpha-methylene-gamma-butyrolactone (alpha-MGBL), on blood-ethanol elevation were investigated in rats. In normal rats, blood-ethanol elevation (30 min later) induced by 20% (v/v) ethanol [5 ml/kg, per os (p.o.)] was strongly inhibited by pretreatment (30 min earlier) with costunolide and alpha-MGBL (50 mg/kg, p.o.). In pylorus-ligated rats given ethanol, blood-ethanol level (30 min) was barely elevated compared with that of normal rats. Neither costunolide nor alpha-MGBL affected the blood-ethanol elevation in pylorus-ligated rats or that induced by intraperitoneal and intraduodenal ethanol administration. Moreover, these compounds given orally induced no irreversible changes in alcohol dehydrogenase activity in rat liver. We continuously investigated the rate of gastric emptying in rats given various test meals. Costunolide and alpha-MGBL suppressed gastric emptying in rats given 20% ethanol and 1% sodium carboxymethyl cellulose. alpha-MGBL (50 mg/kg), but not costunolide, suppressed gastric emptying in 20% glucose-loaded rats. In an in vitro experiment, alpha-MGBL contracted the pylorus strip at a high concentration (20 mM), which was the estimated concentr...Continue Reading

Citations

Aug 3, 2010·Pharmaceutical Biology·Jian DuKhalid Rahman
Nov 26, 2013·The American Journal of Drug and Alcohol Abuse·Irene Joy I Dela PeñaJae Hoon Cheong
Dec 20, 2005·Drug and Alcohol Review·B J XuC K Sung
Feb 6, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Qijuan LiHuiling Hu

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