PMID: 9450913Feb 5, 1998Paper

Inhibitory nonsequence-specific effects of cytidine homopolymers on in vivo neointimal formation

Antisense & Nucleic Acid Drug Development
W WangL E Rabbani

Abstract

Phosphorothioate oligodeoxynucleotides (PS oligos) manifest both antisense and G-quartet aptameric inhibitory effects on vascular smooth muscle cell (SMC) proliferation. In this study, we examined the effects of three cytidine (S-dC) homopolymers lacking any guanosines of various chain length-S-dC28, S-dC18 and S-dC12-on in vitro SMC proliferation and in vivo neointimal formation. S-dC18 significantly inhibited human vascular SMC proliferation, although it had only half the potency as the same dose of S-dC28. Furthermore, S-dC12 at the same concentrations as S-dC18 did not significantly inhibit vascular SMC proliferation. S-dC28 and S-dC18 inhibited PDGF-induced in vitro SMC migration, whereas D-dC12 had no significant effect on PDGF-induced in vitro SMC migration. We determined the effects of S-dC28, S-dC18, and S-dC12 on neointimal SMC formation in the rat carotid balloon injury model. Rat carotid artery neointimal formation after balloon injury was significantly attenuated by S-dC28 treatment compared with the control group and by S-dC18 treatment compared with the control group. S-dC28 and S-dC18 treatment significantly reduced the intima/media area ratio compared with the values of the control groups. However, S-dC12 did n...Continue Reading

References

Mar 1, 1992·Archives of Biochemistry and Biophysics·S J PrestrelskiT Arakawa
Apr 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·A E ErikssonB W Matthews
Jan 1, 1991·Circulation Research·V LindnerM A Reidy
May 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·V Lindner, M A Reidy
May 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·E R EdelmanM J Karnovsky
Aug 1, 1989·The Journal of Cell Biology·P L McNeilP A D'Amore
Apr 25, 1988·Nucleic Acids Research·C A SteinJ S Cohen
Apr 25, 1995·Proceedings of the National Academy of Sciences of the United States of America·T L BurgessT B Kramer
Jan 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·S BiroS E Epstein

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Citations

Nov 11, 1999·Antisense & Nucleic Acid Drug Development·M LeeL E Rabbani
Jun 1, 2004·Nutrition Research Reviews·Paul Christou, Richard M Twyman

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