Inhibitory regulation of inhibin gene expression by thyroid hormone during ovarian development in immature rats

Biochemical and Biophysical Research Communications
Kazuhiro TamuraHiroshi Kogo

Abstract

To explore the role of the thyroid gland in ovarian development during the initiation process of puberty, we examined the effects of hypothyroidism on the secretion of ovarian hormones during equine chorionic gonadotropin (eCG)-induced follicle development in immature female rats. Immature rats at 22 days of age were thyroidectomized (Tx) to cause hypothyroidism and then given a single s.c. injection of 5 IU eCG at 26 days of age to induce normal first ovulation. The blood samples were collected at 0, 24, and 48 h after eCG treatment to measure inhibin and estradiol by radioimmunoassay. Serum inhibin and estradiol levels in eCG-primed Tx animals were significantly higher at 24 and 48 h after eCG treatment than those in controls (eCG treated non-Tx rats). The number of healthy follicles larger than 400 microns in diameter and ovarian weight were significantly increased in Tx rats at 48 h after eCG treatment, compared to those in controls. The number of oocytes which are ovulated by an injection of human chorionic gonadotropin (10 IU) was significantly increased on the day after eCG treatment, compared to that of eCG treated non-Tx rats. The increments in both hormones levels, the number of large antral follicles, and ovarian wei...Continue Reading

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Citations

May 24, 2006·Industrial Health·Soichiro SekiguchiTakeshi Honma
May 6, 2003·Environmental Toxicology and Chemistry·Reynaldo PatiñoTodd A Anderson
Mar 15, 2003·Risk Analysis : an Official Publication of the Society for Risk Analysis·R Thomas Zoeller
Mar 26, 2013·General and Comparative Endocrinology·Diana E K FloodValérie S Langlois
Apr 27, 2004·Journal of Pharmacological Sciences·Minoru HatsutaHiroshi Kogo
May 17, 2018·Biology of Reproduction·Juneo F SilvaRogéria Serakides
May 20, 2000·Annals of the New York Academy of Sciences·A G Doufas, G Mastorakos

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