Inhibitory role for D-alanylation of wall teichoic acid in activation of insect Toll pathway by peptidoglycan of Staphylococcus aureus

The Journal of Immunology : Official Journal of the American Association of Immunologists
Yukichika TabuchiYoshinobu Nakanishi

Abstract

Pathogenic bacteria mitigate host immunity to establish infections, but the mechanism of this bacterial action has not been fully elucidated. To search for cell wall components that modulate innate immune responses in host organisms, we examined Staphylococcus aureus mutants, which were deficient in components of the cell wall, for pathogenicity in Drosophila. A mutation of dltA, which is responsible for the D-alanylation of teichoic acids, brought about an increase in the survival rate of adult flies that had received a septic infection with the bacteria. The growth of dltA-deficient S. aureus in adult flies was less efficient than that of the parental strain. The level of mRNA of Toll pathway-dependent antimicrobial peptides was higher in flies infected with the dltA mutant than that observed after the infection with the parental strain. The defective phenotype associated with the mutation of dltA, reduced pathogenicity and growth, was not evident in flies lacking the Toll pathway. Finally, a fraction of peptidoglycan prepared from the dltA mutant induced the expression of mRNA of a Toll-dependent antimicrobial peptide in flies and was bound by peptidoglycan recognition protein-SA in vitro more effectively than that obtained ...Continue Reading

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Citations

Sep 13, 2012·Microbial Cell Factories·Peter A BronMichiel Kleerebezem
Mar 1, 2012·Journal of Oral Microbiology·Christina O IgboinEugene J Leys
Jun 2, 2015·Antibiotics·Derek R HeimlichKevin M Mason
Jan 13, 2015·Journal of Biochemistry·Qingquan KongYoshinobu Nakanishi
Sep 3, 2014·Developmental and Comparative Immunology·Jack DorlingJens Rolff
Jan 10, 2019·Microbiology·Kyle D BuchanStephen A Renshaw
Apr 3, 2012·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·B A Evans, D E Rozen
Oct 17, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Dong-Jun JungBok Luel Lee
Aug 24, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jang-Hyun AnBok Luel Lee
Jul 14, 2020·Frontiers in Cellular and Infection Microbiology·Salma YounesLayla Kamareddine
Jul 9, 2020·Biochimica Et Biophysica Acta. Proteins and Proteomics·Cindy J LeeJonathan V Sweedler
Aug 28, 2021·The Journal of Antimicrobial Chemotherapy·Delphine CoupriAurélie Budin-Verneuil
Oct 6, 2021·ACS Chemical Biology·Noel J FerraroMarcos M Pires

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