Inhibitory role of large intergenic noncoding RNA-ROR on tamoxifen resistance in the endocrine therapy of breast cancer by regulating the PI3K/Akt/mTOR signaling pathway.

Journal of Cellular Physiology
Peng-Wei LuYuan-Ting Gu

Abstract

Breast cancer (BC) is the second-leading cause of central nervous system metastases among severe malignancies. This study aimed at investigating the underlying mechanism by which large intergenic noncoding RNA-regulator of reprogramming (lincRNA-ROR) affects the tamoxifen (TAM) resistance of BC cells by regulating the PI3K/Akt/mTOR signaling pathway. Immortalized human mammary epithelial cell line (MCF10A) and BC cell lines (MCF-7, MDA-MB-231, T47D, BCAP-37, and ZK-75-1) were cultured, and BC tissues and adjacent normal breast tissues were collected from 152 BC patients. LincRNA-ROR expression in tissues and cells were detected using reverse transcription quantitative polymerase chain reaction. RNA interference was used to silence lincRNA-ROR in MDA-MB-231 cells, and then the cell proliferation and apoptosis were detected by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and annexin-V and propidium iodide (PI) double staining respectively. The expression of apoptosis-related proteins and PI3K/Akt/mTOR signaling pathway-related proteins was measured by performing western blot assay. The BC tissues and cells presented a higher expression of lincRNA-ROR. MAD-MB-231 cells exhibited the highest lincRNA-ROR expres...Continue Reading

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Citations

Sep 5, 2019·Cells·Yujing ChiJichun Yang
Jun 4, 2019·Briefings in Bioinformatics·Feng LiYunpeng Zhang
May 13, 2019·Biochemical Genetics·Yanyan LiuMaoming Xiong
May 27, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Zhong-Shi HongJian-Peng Pan
Feb 26, 2021·Pathology, Research and Practice·Soudeh Ghafouri-FardMohammad Taheri
Nov 19, 2020·Seminars in Cancer Biology·Wangkai XieZhi-Wei Wang
Jun 12, 2021·Cancer Cell International·Jing ChenAlexander Tobias Teichmann

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