Inhibitory synaptic inputs to the oculomotor nucleus from vestibulo-ocular-reflex-related nuclei in the rabbit

Neuroscience
P R WentzelN M Gerrits

Abstract

Studies of the pathways involved in the vestibulo-ocular reflex have suggested that the projection from the superior vestibular nucleus to the ipsilateral oculomotor nucleus is inhibitory, whereas the medial vestibular nucleus, the abducens nucleus and the contralateral superior vestibular nucleus most likely exert excitatory effects on oculomotor neurons. In order to determine directly the termination pattern and the neurotransmitter of these afferents, we studied their input to the oculomotor nucleus in the rabbit at the light microscopic level with the use of anterograde tracing of Phaseolus vulgaris-leucoagglutinin combined with retrograde tracing of horseradish peroxidase from the extraocular muscles, and at the ultrastructural level with the use of anterograde tracing of wheatgerm-agglutinated horseradish peroxidase combined with GABA and glycine postembedding immunocytochemistry. The general ultrastructural characteristics of the neuropil and the types of boutons observed in the rabbit oculomotor nuclei are in general agreement with the descriptions for the oculomotor complex of other mammals. The superior vestibular nucleus projected bilaterally to the superior rectus and inferior oblique subdivisions, and ipsilaterally...Continue Reading

References

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Dec 24, 1993·Neuroscience Letters·P R WentzelN M Gerrits

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Citations

Dec 24, 1993·Neuroscience Letters·P R WentzelN M Gerrits
Nov 14, 2000·Journal of Neuroscience Methods·T DellerM Frotscher
Nov 1, 1995·The European Journal of Neuroscience·C I De Zeeuw, A S Berrebi
Jun 8, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Takashi KodamaSascha du Lac
Apr 4, 2000·Physiological Reviews·J C ReklingJ L Feldman

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