Inhibitory synaptic transmission governs inspiratory motoneuron synchronization

Journal of Neurophysiology
J Y SebeA J Berger

Abstract

Neurons within the intact respiratory network produce bursts of action potentials that cause inspiration or expiration. Within inspiratory bursts, activity is synchronized on a shorter timescale to generate clusters of action potentials that occur in a set frequency range and are called synchronous oscillations. We investigated how GABA and glycine modulate synchronous oscillations and respiratory rhythm during postnatal development. We recorded inspiratory activity from hypoglossal nerves using the in vitro rhythmically active mouse medullary slice preparation from P0-P11 mice. Average oscillation frequency increased with postnatal development, from 17 +/- 12 Hz in P0-P6 mice (n = 15) to 38 +/- 7 Hz in P7-P11 mice (n = 37) (P < 0.0001). Bath application of GABAA and GlyR antagonists significantly reduced oscillation power in neonates (P0-P6) and juveniles (P7-P10) and increased peak integrated activity in both age groups. To test whether elevating slice excitability is sufficient to reduce oscillation power, Substance P was bath applied alone. Substance P, although increasing peak integrated activity, had no significant effect on oscillation power. Prolonging the time course of GABAergic synaptic currents with zolpidem decreas...Continue Reading

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Citations

Nov 5, 2010·Journal of Neurophysiology·J F M van Brederode, A J Berger
Apr 4, 2008·Journal of Neurophysiology·Johannes F M van Brederode, Albert J Berger
Dec 23, 2006·The Journal of Physiology·Simon F FarmerJohn A Stephens
Jul 12, 2011·Respiratory Physiology & Neurobiology·Ralph F Fregosi
Mar 9, 2011·Respiratory Physiology & Neurobiology·Albert J Berger
Feb 3, 2007·Respiratory Physiology & Neurobiology·Albert J Berger, Joy Sebe
Feb 17, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Peter M Lalley, Steve W Mifflin
Oct 17, 2006·The Journal of Biological Chemistry·Gonzalo E YevenesLuis G Aguayo
Jan 17, 2020·ELife·Alicia N VagnozziPolyxeni Philippidou
Aug 5, 2015·Journal of Neurotrauma·Michael George Zaki Ghali, Vitaliy Marchenko
Sep 24, 2020·Journal of Neurophysiology·Lauren S SegersBruce G Lindsey

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