Inhibitory TCR coreceptor PD-1 is a sensitive indicator of low-level replication of SIV and HIV-1.

The Journal of Immunology : Official Journal of the American Association of Immunologists
Nadine C SalischR Paul Johnson

Abstract

Ongoing antigenic stimulation appears to be an important prerequisite for the persistent expression of programmed death 1 (PD-1), an inhibitory TCR coreceptor of the CD28 family. Although recent publications have emphasized the utility of PD-1 as a marker for dysfunctional T cells in chronic viral infections, its dependence on antigenic stimulation potentially renders it a sensitive indicator of low-level viral replication. To explore the antigenic threshold for the maintenance of PD-1 expression on virus-specific T cells, we compared PD-1 expression on virus-specific and memory T cell populations in controlled and uncontrolled SIV and HIV-1 infection. In both controlled live attenuated SIV infection in rhesus macaques and HIV-1 infection in elite controllers, elevated levels of PD-1 expression were observed on SIV- and HIV-1-specific CD8(+) T cells. However, in contrast to chronic wild-type SIV infection and uncontrolled HIV-1 infection, controlled SIV/HIV-1 infection did not result in increased expression of PD-1 on total memory T cells. PD-1 expression on SIV-specific CD8(+) T cells rapidly decreased after the emergence of CTL escape in cognate epitopes, but was maintained in the setting of low or undetectable levels of plas...Continue Reading

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Citations

Dec 27, 2011·Current HIV/AIDS Reports·Filippos Porichis, Daniel E Kaufmann
Sep 11, 2012·Nature Medicine·Yoshinori FukazawaLouis J Picker
Apr 4, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Wenjin FanQingsheng Li
Jan 2, 2018·The Open AIDS Journal·Antonio MarraFrancesco Sabbatino
Nov 7, 2019·Journal of Virology·Lisa J HendersonAvindra Nath
Jul 16, 2014·Current Opinion in HIV and AIDS·Colleen S McGaryMirko Paiardini
Aug 7, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gaëlle BretonRafick-Pierre Sékaly
Aug 20, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Qingsheng LiAshley T Haase
Jul 27, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Afework KassuBrent E Palmer
May 13, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Joseph A ConradSpyros A Kalams
Feb 13, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ming ZengAshley T Haase

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