PMID: 8946328Nov 6, 1996Paper

Inhibitory transmission to the longitudinal muscle of the mouse caecum is mediated largely by nitric oxide acting via soluble guanylyl cyclase

Journal of the Autonomic Nervous System
H M YoungM J Stebbing

Abstract

In this work we describe a region of mouse intestine, the caecum, in which inhibitory transmission to the longitudinal muscle is predominantly due to nitric oxide. In the presence of muscarinic receptor blockade, electrical stimulation of intramural nerves in the longitudinal muscle of the mouse caecum evoked a relaxation. The relaxation was reduced to about 25% of the control amplitude by the nitric oxide synthase inhibitor L-NMMA (NG-methyl-L-arginine), but was unaffected by D-NMMA. In the presence of the nitric oxide scavenger oxyhaemoglobin, the relaxation was reduced to less than 10% of the control amplitude. In the circular muscle of the caecum and the longitudinal muscle of the ileum, colon and rectum, electrical field stimulation either evoked only small relaxations, or relaxations that were unaffected by L-NMMA. Nitric oxide synthase-containing neurons in the caecum were localized immunohistochemically using an antibody to neuronal nitric oxide synthase or with NADPH diaphorase histochemistry. Reactive nerve cell bodies were observed in the myenteric plexus, and varicose nerve fibres were present in the longitudinal and circular muscle layers of the caecum. The transduction mechanism of the nitric oxide-mediated relaxa...Continue Reading

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Citations

Jun 29, 1999·Journal of Autonomic Pharmacology·M V BarahonaM San Andrés
Jul 9, 2010·World Journal of Gastroenterology : WJG·Randa-M MostafaHosam Hamdy
Jul 12, 2005·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Yutaka OkishioFumiaki Hata
Jun 13, 2009·Brain Research Reviews·P Garcia-LopezM Freire
Dec 24, 2003·Autonomic & Autacoid Pharmacology·C H JunU D Sohn
Jan 30, 2009·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·S IinoK M Sanders
May 15, 2002·The Journal of Pharmacy and Pharmacology·Natale Alfredo SantagatiSanti Spampinato
Dec 8, 2005·Canadian Journal of Physiology and Pharmacology·Maria Grazia ZizzoRosa Serio
Jul 6, 2014·Physiological Reviews·Kenton M SandersSang Don Koh
Dec 18, 2019·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Sara TraserraMarcel Jimenez
Nov 14, 1998·The American Journal of Physiology·R K Goyal, X D He
Jul 26, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Andrei SibaevMartin Storr
Mar 26, 2009·Reproductive Sciences·Cresta Wedel JonesGeorge Osol
Oct 17, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Christian F MangHeinz Kilbinger
Dec 16, 2004·Journal of Pharmacological Sciences·Akikazu FujitaFumiaki Hata

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