Inhomogeneous derangement of cardiac autonomic nerve control in diabetic rats

Circulation Journal : Official Journal of the Japanese Circulation Society
Shamarendra N SanyalKatsushige Ono

Abstract

The present study compared autonomic nervous function in Kob [Spontaneously Diabetic, Bio-Breeding (BB)] rats with control Wistar rats to determine the development of cardiac neuropathy in diabetic rats. Telemetric ECG signals were obtained from an ECG radio-transmitter placed in a dorsal subcutaneous pouch of male Kob and Wistar rats for 30min every 6h at a sample rate of 5kHz. Heart rate (HR) and HR variability (HRV) were analyzed in each group by power spectrograms obtained by a fast Fourier transform algorithm. RR interval, total power (TP), low frequency (LF) power (0.04-0.67 Hz), high frequency (HF) power (0.79-1.48 Hz) and LF/HF ratio were also measured. The Kob rats had lower HRV than the control Wistar rats; HR, TP, and HF power, but not the LF/HF ratio, in the Kob rats were significantly lower than those of the control rats (p<0.001). However, in the Kob rats the response of these parameters to a muscarinic antagonist (atropine: 2mg/kg) was left intact, but their response to a beta-adrenergic antagonist (propranolol: 4mg/kg) was impeded. Autonomic nervous control of HR in spontaneously diabetic rats was inhomogeneously deranged in terms of the balance in sympathetic and parasympathetic tone, not only in the baseline c...Continue Reading

References

Dec 10, 1979·Life Sciences·J J Savarese, B A Berkowitz
Oct 1, 1979·Diabetologia·B F ClarkeI W Campbell
Sep 1, 1976·Diabetes·R H Lloyd-Mostyn, P J Watkins
May 1, 1983·Diabetologia·S A Smith, S E Smith
Jan 1, 1982·Medit︠s︡inskai︠a︡ sestra·L S Manvelov
May 1, 1994·American Heart Journal·P K SteinB M Conger
Mar 15, 1993·Annals of Internal Medicine·C M van Ravenswaaij-ArtsH P van Geijn
Oct 22, 1998·Journal of Cardiovascular Pharmacology·L ManginF Carré
Jul 8, 1999·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·T WadaM Arita

❮ Previous
Next ❯

Citations

Dec 14, 2005·European Journal of Applied Physiology·Pedro P Pereira-JuniorJosé H M Nascimento
Oct 3, 2012·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Shamarendra N SanyalKatsushige Ono
Aug 22, 2008·International Journal of Experimental Pathology·I-Min LiuJuei-Tang Cheng
Jul 20, 2012·Autonomic Neuroscience : Basic & Clinical·Chikodi N AnigboguDavid C Randall
Jun 22, 2010·Anais Da Academia Brasileira De Ciências·Pedro P Pereira-JuniorJosé H M Nascimento
Mar 15, 2005·Inhalation Toxicology·Volker HarderHolger Schulz
Jul 23, 2008·Bulletin of Experimental Biology and Medicine·E V Sal'nikovM V Grigor'eva
May 15, 2013·Journal of Neurogastroenterology and Motility·Ingrid DemedtsJan Tack
May 15, 2013·Journal of Neurogastroenterology and Motility·Kyung Sik Park
Feb 21, 2021·Clinical and Experimental Pharmacology & Physiology·Ahmed SultanFrank Christopher Howarth
Jan 20, 2012·Cardiovascular Diabetology·Zhih-Cherng ChenJuei- Tang Cheng
Oct 5, 2021·Experimental Physiology·Ruy Andrade LouzadaDenise Pires Carvalho

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved