Inhomogeneous distribution of filipin-sterol complexes in the ciliary membrane of rat tracheal epithelium

The American Journal of Anatomy
R Montesano

Abstract

Pieces of rat trachea fixed in a glutaraldehyde solution containing 300 muM filipin, a sterol-specific polyene antibiotic (Elias et al., '78), were freeze-fractured in order to study the distribution of cholesterol within the ciliary membrane. Filipin-sterol complexes, recognizable as 25-30-nm protrusions on fracture faces, appeared densely and uniformly distributed over most of the ciliary membrane, but were absent from the region of the ciliary necklace. It is possible, therefore, that the ciliary necklace represents a cholesterol-poor area of membrane.

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Jul 1, 1981·The Histochemical Journal·D S Friend, E L Bearer
Jul 7, 2009·Annual Review of Cell and Developmental Biology·Maxence V NachuryHua Jin
Apr 20, 2010·Current Opinion in Cell Biology·Rajat Rohatgi, William J Snell
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Apr 6, 2019·Nature Reviews. Molecular Cell Biology·Maxence V Nachury, David U Mick
Aug 28, 2020·Frontiers in Cell and Developmental Biology·Inna V Nechipurenko

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